DegronMD

Uniprot ID: P14543

Source protein: Nidogen-1

Source gene: NID1

Class: DEG_APCC_DBOX_1

Location: 301:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.985

ASA_SCORE: 73.9

COIL: 0.7137

CONS_SCORE: 0.2741

DSS_SCORE: 0.3791

HELIX: 0.0908

FCONS_SCORE: 0.9489

RIG_SCORE: 0.7925

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T311M	TCGA-44-7670	LUAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.T311M	TCGA-EA-A410	CESC	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.T311M	DO49929	CESC	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.T311M	DO23555	LUAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.T311M	SIDM00607	Glioblastoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.T311M	KNS-42	central_nervous_system	COSMIC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.L318V	TCGA-AO-A0J6	BRCA	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	0.0833
p.L318V	DO4233	BRCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.0833
p.E306D	TCGA-IB-7651	PAAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	0.5647
p.E306D	TCGA-VQ-AA6J	STAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	0.5647
p.E306D	DO46657	PAAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.5647
p.E306D	DO51802	STAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.5647
p.G304C	TCGA-MN-A4N4	LUAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	0.6489
p.G304C	DO26250	LUAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.6489
p.A299V	DO227774	COCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.A299V	DO222523	COCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.A299V	SIDM00660	Colorectal Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.A299V	SIDM01397	Melanoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2778
p.Y296C	DO227987	COCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.1944
p.K316R	DO234254	ESAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.25
p.R319G	DO234304	ESAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.0556
p.K316T	DO233804	GACA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.25
p.A317D	DO229031	LICA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.1111
p.S314F	DO220891	MELA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.1944
p.R302C	DO222743	MELA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8301
p.R302H	SIDM00672	Hepatocellular Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01090	Colorectal Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01126	Small Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00656	Burkitt's Lymphoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00849	Kidney Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00032	Bladder Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01133	Other Solid Cancers	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00863	Burkitt's Lymphoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM00641	Burkitt's Lymphoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01664	Prostate Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.R302H	SIDM01752	Pancreatic Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.8244
p.F313L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2222
p.F313L	ACH-000551	Leukemia	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	0.2222
p.F313L	ACH-002061	Leukemia	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	0.2222
p.F313L	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	TRLGLEDVG	DEG_APCC_DBOX_1	0.2222
p.D293N	SIDM00806	Osteosarcoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	0.1111
p.D293N	ACH-000613	Bone Cancer	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	0.1111
p.D293N	ACH-001001	Bone Cancer	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	0.1111
p.D293N	HOS	bone	COSMIC	TRLGLEDVG	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRLGLEDVG

Degron related mutations and impact score

Drug responses associated with NID1 mutations

All proteins holding degron of TRLGLEDVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14543	Nidogen-1	DEG_APCC_DBOX_1	301:309	TRLGLEDVG	APC,CDC20,FZR1	0.985	More...