DegronMD

Uniprot ID: Q99715

Source protein: Collagen alpha-1

Source gene: COL12A1

Class: DEG_Kelch_Keap1_1

Location: 945:950

E3 ligase: KEAP1

DEGRON score: 0.685

ASA_SCORE: 79.8333

COIL: 0.5005

CONS_SCORE: 0.4922

DSS_SCORE: 0.3316

HELIX: 0.017

FCONS_SCORE: 1.0974

RIG_SCORE: 0.7674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D945Y	TCGA-AP-A1E0	UCEC	TCGA	DVDTGE	DEG_Kelch_Keap1_1	0.7325
p.D945Y	DO43154	UCEC	ICGC	DVDTGE	DEG_Kelch_Keap1_1	0.7325
p.R936M	TCGA-EE-A3AC	SKCM	TCGA	DVDTGE	DEG_Kelch_Keap1_1	0.0833
p.R936M	DO37631	SKCM	ICGC	DVDTGE	DEG_Kelch_Keap1_1	0.0833
p.N952I	DO45209	LIRI	ICGC	DVDTGE	DEG_Kelch_Keap1_1	0.2778
p.V937A	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	DVDTGE	DEG_Kelch_Keap1_1	0.1111
p.V937A	ACH-000886	Lung Cancer	CCLE	DVDTGE	DEG_Kelch_Keap1_1	0.1111
p.V937A	NCI-H2009	lung	COSMIC	DVDTGE	DEG_Kelch_Keap1_1	0.1111
p.Y935C	CAL-120	breast	COSMIC	DVDTGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99715	Collagen alpha-1	DEG_Kelch_Keap1_1	945:950	DVDTGE	KEAP1	0.685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons