DegronMD

Uniprot ID: Q3ZCN5

Source protein: Otogelin-like protein

Source gene: OTOGL

Class: CBL_PTK

Location: 2169:2178

E3 ligase: CBL

DEGRON score: 0.5277

ASA_SCORE: 80.06

COIL: 0.6899

CONS_SCORE: 0

DSS_SCORE: 0.023

HELIX: 0.0183

FCONS_SCORE: 0

RIG_SCORE: 0.8115

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2171N	TCGA-49-6767	LUAD	TCGA	DVHQVYTPSP	CBL_PTK	0.6932
p.P2169S	TCGA-AC-A5XU	BRCA	TCGA	DVHQVYTPSP	CBL_PTK	0.6752
p.V2181I	TCGA-AY-6197	COAD	TCGA	DVHQVYTPSP	CBL_PTK	0.25
p.G2176S	TCGA-D5-6930	COAD	TCGA	DVHQVYTPSP	CBL_PTK	0.6993
p.G2176V	TCGA-E6-A1LX	UCEC	TCGA	DVHQVYTPSP	CBL_PTK	0.7532
p.S2182F	TCGA-FR-A726	SKCM	TCGA	DVHQVYTPSP	CBL_PTK	0.2222
p.V2181L	TCGA-GM-A2DH	BRCA	TCGA	DVHQVYTPSP	CBL_PTK	0.25
p.E2188K	TCGA-GN-A8LK	SKCM	TCGA	DVHQVYTPSP	CBL_PTK	0.1667
p.G2185D	SIDM00216	Colorectal Carcinoma	GDSC	DVHQVYTPSP	CBL_PTK	0.1389
p.G2185D	SNU-175	large_intestine	COSMIC	DVHQVYTPSP	CBL_PTK	0.1389
p.V2170F	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DVHQVYTPSP	CBL_PTK	0.5957
p.V2170F	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	DVHQVYTPSP	CBL_PTK	0.5957
p.G2182D	SIDM00527	Colorectal Carcinoma	GDSC	DVHQVYTPSP	CBL_PTK	0.2222
p.G2182D	MDST8	large_intestine	COSMIC	DVHQVYTPSP	CBL_PTK	0.2222
p.G2161D	ACH-000935	Colon/Colorectal Cancer	CCLE	DVHQVYTPSP	CBL_PTK	0.1111
p.G2164D	ACH-000989	Colon/Colorectal Cancer	CCLE	DVHQVYTPSP	CBL_PTK	0.1944
p.A2184T	ACH-000999	Colon/Colorectal Cancer	CCLE	DVHQVYTPSP	CBL_PTK	0.1667
p.Y2160C	ACH-001369	Ovarian Cancer	CCLE	DVHQVYTPSP	CBL_PTK	0.0833
p.E2173A	HCC2998	large_intestine	COSMIC	DVHQVYTPSP	CBL_PTK	0.7701
p.V2161F	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	DVHQVYTPSP	CBL_PTK	0.1111
p.A2160T	SNU-1040	large_intestine	COSMIC	DVHQVYTPSP	CBL_PTK	0.0833
p.G2173D	MDST8	large_intestine	COSMIC	DVHQVYTPSP	CBL_PTK	0.7198
p.G2176D	SNU-175	large_intestine	COSMIC	DVHQVYTPSP	CBL_PTK	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3ZCN5	Otogelin-like protein	CBL_PTK	2169:2178	DVHQVYTPSP	CBL	0.5277	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons