DegronMD - Q3ZCN5(OTOGL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V288E	TCGA-17-Z022	LUAD	TCGA	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7693
p.D2171N	TCGA-49-6767	LUAD	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.6932
p.P297Q	TCGA-85-A4JB	LUSC	TCGA	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.P297Q	DO45517	LUSC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.P2169S	TCGA-AC-A5XU	BRCA	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.6752
p.V2181I	TCGA-AY-6197	COAD	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.25
p.P282T	TCGA-D3-A3CE	SKCM	TCGA	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.P282T	DO23204	LINC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.P282T	DO37405	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.G2176S	TCGA-D5-6930	COAD	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.6993
p.G2176V	TCGA-E6-A1LX	UCEC	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.7532
p.P297S	TCGA-EE-A3AB	SKCM	TCGA	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.P297S	DO222670	MELA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.P297S	DO38057	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.S300I	TCGA-ER-A19N	SKCM	TCGA	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.S300I	DO37452	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.S2182F	TCGA-FR-A726	SKCM	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.2222
p.V2181L	TCGA-GM-A2DH	BRCA	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.25
p.E2188K	TCGA-GN-A8LK	SKCM	TCGA	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation substituting flanking lysine	0.1667
p.V288L	TCGA-HZ-7925	PAAD	TCGA	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.5654
p.V288L	DO32778	PAAD	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.5654
p.S278L	DO230347	COCA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0556
p.S278L	DO45299	LIRI	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0556
p.C303Y	DO233882	GACA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0833
p.Q295K	DO14766	HNSC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.3056
p.P297H	DO22542	LGG	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.C292Y	DO228192	LICA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7087
p.C292Y	DO50970	LICA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7087
p.D304Y	DO24900	LUAD	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0556
p.D304Y	DO38467	STAD	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0556
p.D291Y	DO26462	LUSC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7325
p.C292G	DO29166	OV	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.76
p.P282L	DO229470	SKCA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.S285L	DO50301	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.D291V	DO229240	THCA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7785
p.Q279H	DO50076	UCEC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0833
p.I298M	DO42977	UCEC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.2222
p.Q290H	DO42713	UCEC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7582
p.G2185D	SIDM00216	Colorectal Carcinoma	GDSC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.1389
p.G2185D	SNU-175	large intestine	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.1389
p.V2170F	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.5957
p.V2170F	BV-173	haematopoietic and lymphoid tissue	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.5957
p.C296Y	SIDM00254	Neuroblastoma	GDSC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.2778
p.C296Y	NB5	autonomic ganglia	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.2778
p.G2182D	SIDM00527	Colorectal Carcinoma	GDSC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.2222
p.G2182D	MDST8	large intestine	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.2222
p.P300H	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.P300H	IA-LM	lung	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1667
p.A280T	SIDM00359	Colorectal Carcinoma	GDSC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1111
p.A280T	RCM-1	large intestine	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1111
p.S299F	ACH-000605	Esophageal Cancer	CCLE	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1944
p.S299F	TE-6	oesophagus	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1944
p.P291H	ACH-000672	Lung Cancer	CCLE	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7694
p.P291H	IA-LM	lung	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.7694
p.G2161D	ACH-000935	Colon/Colorectal Cancer	CCLE	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.1111
p.G2164D	ACH-000989	Colon/Colorectal Cancer	CCLE	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.1944
p.A2184T	ACH-000999	Colon/Colorectal Cancer	CCLE	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.1667
p.Y2160C	ACH-001369	Ovarian Cancer	CCLE	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.0833
p.C287Y	ACH-002283	Neuroblastoma	CCLE	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.3056
p.C287Y	NB5	autonomic ganglia	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.3056
p.V288I	ACH-002287	Colon/Colorectal Cancer	CCLE	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.5965
p.V288I	NCI-H630	large intestine	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.5965
p.E2173A	HCC2998	large intestine	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.7701
p.V297I	NCI-H630	large intestine	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.25
p.V2161F	BV-173	haematopoietic and lymphoid tissue	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.1111
p.A2160T	SNU-1040	large intestine	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation rewiring degron network	0.0833
p.G2173D	MDST8	large intestine	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.7198
p.G2176D	SNU-175	large intestine	COSMIC	DVHQVYTPSP	CBL_PTK	2169:2178	Mutation altering degron motif	0.7198

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTOGL

UniProt ID: Q3ZCN5

Entrez ID:

Protein name: Otogelin-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTOGL in