DegronMD

Uniprot ID: Q3ZCN5

Source protein: Otogelin-like protein

Source gene: OTOGL

Class: DEG_SCF_FBW7_1

Location: 288:294

E3 ligase: FBXW7

DEGRON score: 0.6095

ASA_SCORE: 77.7429

COIL: 0.8876

CONS_SCORE: 0.3545

DSS_SCORE: 0.273

HELIX: 0.0559

FCONS_SCORE: 1.0098

RIG_SCORE: 0.7794

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V288E	TCGA-17-Z022	LUAD	TCGA	VQTPDDT	DEG_SCF_FBW7_1	0.7693
p.P297Q	TCGA-85-A4JB	LUSC	TCGA	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.P297Q	DO45517	LUSC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.P282T	TCGA-D3-A3CE	SKCM	TCGA	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.P282T	DO23204	LINC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.P282T	DO37405	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.P297S	TCGA-EE-A3AB	SKCM	TCGA	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.P297S	DO222670	MELA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.P297S	DO38057	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.S300I	TCGA-ER-A19N	SKCM	TCGA	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.S300I	DO37452	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.V288L	TCGA-HZ-7925	PAAD	TCGA	VQTPDDT	DEG_SCF_FBW7_1	0.5654
p.V288L	DO32778	PAAD	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.5654
p.S278L	DO230347	COCA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.0556
p.S278L	DO45299	LIRI	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.0556
p.C303Y	DO233882	GACA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.0833
p.Q295K	DO14766	HNSC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.3056
p.P297H	DO22542	LGG	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.C292Y	DO228192	LICA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.7087
p.C292Y	DO50970	LICA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.7087
p.D304Y	DO24900	LUAD	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.0556
p.D304Y	DO38467	STAD	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.0556
p.D291Y	DO26462	LUSC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.7325
p.C292G	DO29166	OV	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.76
p.P282L	DO229470	SKCA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.S285L	DO50301	SKCM	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.25
p.D291V	DO229240	THCA	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.7785
p.Q279H	DO50076	UCEC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.0833
p.I298M	DO42977	UCEC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.2222
p.Q290H	DO42713	UCEC	ICGC	VQTPDDT	DEG_SCF_FBW7_1	0.7582
p.C296Y	SIDM00254	Neuroblastoma	GDSC	VQTPDDT	DEG_SCF_FBW7_1	0.2778
p.C296Y	NB5	autonomic_ganglia	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.2778
p.P300H	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.P300H	IA-LM	lung	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.1667
p.A280T	SIDM00359	Colorectal Carcinoma	GDSC	VQTPDDT	DEG_SCF_FBW7_1	0.1111
p.A280T	RCM-1	large_intestine	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.1111
p.S299F	ACH-000605	Esophageal Cancer	CCLE	VQTPDDT	DEG_SCF_FBW7_1	0.1944
p.S299F	TE-6	oesophagus	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.1944
p.P291H	ACH-000672	Lung Cancer	CCLE	VQTPDDT	DEG_SCF_FBW7_1	0.7694
p.P291H	IA-LM	lung	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.7694
p.C287Y	ACH-002283	Neuroblastoma	CCLE	VQTPDDT	DEG_SCF_FBW7_1	0.3056
p.C287Y	NB5	autonomic_ganglia	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.3056
p.V288I	ACH-002287	Colon/Colorectal Cancer	CCLE	VQTPDDT	DEG_SCF_FBW7_1	0.5965
p.V288I	NCI-H630	large_intestine	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.5965
p.V297I	NCI-H630	large_intestine	COSMIC	VQTPDDT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQTPDDT

Degron related mutations and impact score

Drug responses associated with OTOGL mutations

All proteins holding degron of VQTPDDT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3ZCN5	Otogelin-like protein	DEG_SCF_FBW7_1	288:294	VQTPDDT	FBXW7	0.6095	More...