DegronMD

Uniprot ID: Q99848

Source protein: Probable rRNA-processing protein EBP2

Source gene: EBNA1BP2

Class: DEG_COP1_1

Location: 71:80

E3 ligase: COP1

DEGRON score: 0.9042

ASA_SCORE: 57.68

COIL: 0.6663

CONS_SCORE: 0.3372

DSS_SCORE: 0.4812

HELIX: 0.0171

FCONS_SCORE: 1.0285

RIG_SCORE: 0.7399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E65Q	TCGA-63-A5MS	LUSC	TCGA	DVTLGPVPEI	DEG_COP1_1	0.1667
p.E65Q	DO219161	LUSC	ICGC	DVTLGPVPEI	DEG_COP1_1	0.1667
p.E67D	TCGA-AP-A1DV	UCEC	TCGA	DVTLGPVPEI	DEG_COP1_1	0.2222
p.E67D	DO43186	UCEC	ICGC	DVTLGPVPEI	DEG_COP1_1	0.2222
p.D80G	TCGA-DD-A1EJ	LIHC	TCGA	DVTLGPVPEI	DEG_COP1_1	0.7198
p.D80G	DO22994	LIHC	ICGC	DVTLGPVPEI	DEG_COP1_1	0.7198
p.R76K	DO48428	BLCA	ICGC	DVTLGPVPEI	DEG_COP1_1	0.7237
p.R76K	SIDM01690	Plasma Cell Myeloma	GDSC	DVTLGPVPEI	DEG_COP1_1	0.7237
p.L86I	DO229031	LICA	ICGC	DVTLGPVPEI	DEG_COP1_1	0.1667
p.E67K	DO229050	LICA	ICGC	DVTLGPVPEI	DEG_COP1_1	0.2222
p.V73A	SIDM00118	Colorectal Carcinoma	GDSC	DVTLGPVPEI	DEG_COP1_1	0.6936
p.V73A	HCC2998	large_intestine	COSMIC	DVTLGPVPEI	DEG_COP1_1	0.6936
p.G81S	ACH-000953	Leukemia	CCLE	DVTLGPVPEI	DEG_COP1_1	0.3056
p.G81S	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DVTLGPVPEI	DEG_COP1_1	0.3056
p.V72A	ACH-000985	Colon/Colorectal Cancer	CCLE	DVTLGPVPEI	DEG_COP1_1	0.5825
p.V72A	LS-411N	large_intestine	COSMIC	DVTLGPVPEI	DEG_COP1_1	0.5825
p.E68K	ACH-001138	Lung Cancer	CCLE	DVTLGPVPEI	DEG_COP1_1	0.25
p.E68K	NCI-H2141	lung	COSMIC	DVTLGPVPEI	DEG_COP1_1	0.25
p.G81V	ACH-002222	Leukemia	CCLE	DVTLGPVPEI	DEG_COP1_1	0.3056
p.G81V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DVTLGPVPEI	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99848	Probable rRNA-processing protein EBP2	DEG_COP1_1	71:80	DVTLGPVPEI	COP1	0.9042	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons