DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
DYRDFEYSGPP
Uniprot ID:
Q5VT52
Source protein:
Regulation of nuclear pre-mRNA domain-containing protein 2
Source gene:
RPRD2
Class:
CBL_PTK
Location:
832:842
E3 ligase:
CBL
DEGRON score:
0.996
ASA_SCORE:
89.9909
COIL:
0.7977
CONS_SCORE:
0.3954
DSS_SCORE:
0.6351
HELIX:
0.1833
FCONS_SCORE:
1.1377
RIG_SCORE:
0.6953
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S826Y
TCGA-AG-A002
READ
TCGA
DYRDFEYSGPP
CBL_PTK
0.6111
p.P842S
TCGA-CK-4951
COAD
TCGA
DYRDFEYSGPP
CBL_PTK
0.6752
p.D824E
TCGA-DD-AAVV
LIHC
TCGA
DYRDFEYSGPP
CBL_PTK
0.1111
p.S839A
TCGA-EO-A22R
UCEC
TCGA
DYRDFEYSGPP
CBL_PTK
0.7588
p.Y822C
TCGA-VQ-AA6G
STAD
TCGA
DYRDFEYSGPP
CBL_PTK
0.0556
p.E842K
DO230334
COCA
ICGC
DYRDFEYSGPP
CBL_PTK
0.7022
p.L832M
DO22237
LGG
ICGC
DYRDFEYSGPP
CBL_PTK
0.711
p.K836N
DO229036
LICA
ICGC
DYRDFEYSGPP
CBL_PTK
0.6918
p.P845S
DO222395
MELA
ICGC
DYRDFEYSGPP
CBL_PTK
0.25
p.L847M
DO42280
UCEC
ICGC
DYRDFEYSGPP
CBL_PTK
0.1944
p.K829N
DO42568
UCEC
ICGC
DYRDFEYSGPP
CBL_PTK
0.25
p.S830F
DO41361
UCEC
ICGC
DYRDFEYSGPP
CBL_PTK
0.2778
p.E831G
SIDM01045
Endometrial Carcinoma
GDSC
DYRDFEYSGPP
CBL_PTK
0.3056
p.E831G
ACH-000978
Endometrial/Uterine Cancer
CCLE
DYRDFEYSGPP
CBL_PTK
0.3056
p.E831G
EN
endometrium
COSMIC
DYRDFEYSGPP
CBL_PTK
0.3056
p.M846V
SIDM00276
Biliary Tract Carcinoma
GDSC
DYRDFEYSGPP
CBL_PTK
0.2222
p.M846V
SIDM01210
Glioblastoma
GDSC
DYRDFEYSGPP
CBL_PTK
0.2222
p.S835N
KYSE-270
oesophagus
COSMIC
DYRDFEYSGPP
CBL_PTK
0.7069
Drug responses associated with RPRD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DYRDFEYSGPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VT52
Regulation of nuclear pre-mRNA domain-containing protein 2
CBL_PTK
832:842
DYRDFEYSGPP
CBL
0.996
More...