DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_COP1_1

Location: 11080:11088

E3 ligase: COP1

DEGRON score: 0.9855

ASA_SCORE: 89.7111

COIL: 0.914

CONS_SCORE: 0

DSS_SCORE: 0.5509

HELIX: 0.0154

FCONS_SCORE: 0

RIG_SCORE: 0.6358

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P11092H	TCGA-35-4123	LUAD	TCGA	EASSAVPTP	DEG_COP1_1	0.2222
p.P11092H	DO26394	LUAD	ICGC	EASSAVPTP	DEG_COP1_1	0.2222
p.T11070I	TCGA-49-AAR9	LUAD	TCGA	EASSAVPTP	DEG_COP1_1	0.0556
p.T11070I	DO218921	LUAD	ICGC	EASSAVPTP	DEG_COP1_1	0.0556
p.A11084D	TCGA-55-6979	LUAD	TCGA	EASSAVPTP	DEG_COP1_1	0.6682
p.A11084D	DO24110	LUAD	ICGC	EASSAVPTP	DEG_COP1_1	0.6682
p.A11081P	TCGA-55-A491	LUAD	TCGA	EASSAVPTP	DEG_COP1_1	0.6392
p.A11081P	DO25787	LUAD	ICGC	EASSAVPTP	DEG_COP1_1	0.6392
p.H11077N	TCGA-86-8055	LUAD	TCGA	EASSAVPTP	DEG_COP1_1	0.25
p.H11077N	DO25554	LUAD	ICGC	EASSAVPTP	DEG_COP1_1	0.25
p.A11079V	TCGA-BR-7958	STAD	TCGA	EASSAVPTP	DEG_COP1_1	0.3056
p.A11079V	DO38344	STAD	ICGC	EASSAVPTP	DEG_COP1_1	0.3056
p.S11083L	TCGA-EB-A430	SKCM	TCGA	EASSAVPTP	DEG_COP1_1	0.6556
p.S11083L	DO37906	SKCM	ICGC	EASSAVPTP	DEG_COP1_1	0.6556
p.G11096E	TCGA-EE-A29L	SKCM	TCGA	EASSAVPTP	DEG_COP1_1	0.1111
p.G11096E	DO222599	MELA	ICGC	EASSAVPTP	DEG_COP1_1	0.1111
p.G11096E	DO37835	SKCM	ICGC	EASSAVPTP	DEG_COP1_1	0.1111
p.G11093R	TCGA-EE-A29V	SKCM	TCGA	EASSAVPTP	DEG_COP1_1	0.1944
p.G11093R	DO38006	SKCM	ICGC	EASSAVPTP	DEG_COP1_1	0.1944
p.G11093V	TCGA-EE-A2GT	SKCM	TCGA	EASSAVPTP	DEG_COP1_1	0.1944
p.G11093V	DO37946	SKCM	ICGC	EASSAVPTP	DEG_COP1_1	0.1944
p.S11083P	TCGA-VQ-A8DU	STAD	TCGA	EASSAVPTP	DEG_COP1_1	0.5641
p.S11083P	DO51752	STAD	ICGC	EASSAVPTP	DEG_COP1_1	0.5641
p.A11074T	DO894	BOCA	ICGC	EASSAVPTP	DEG_COP1_1	0.1667
p.A11081V	DO222404	BTCA	ICGC	EASSAVPTP	DEG_COP1_1	0.5825
p.S11083T	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	EASSAVPTP	DEG_COP1_1	0.6005
p.S11083T	ACH-000438	Lung Cancer	CCLE	EASSAVPTP	DEG_COP1_1	0.6005
p.S11083T	LU-65	lung	COSMIC	EASSAVPTP	DEG_COP1_1	0.6005
p.S11082R	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	EASSAVPTP	DEG_COP1_1	0.7427
p.S11082R	ACH-000438	Lung Cancer	CCLE	EASSAVPTP	DEG_COP1_1	0.7427
p.S11082R	LU-65	lung	COSMIC	EASSAVPTP	DEG_COP1_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EASSAVPTP

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of EASSAVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_COP1_1	11080:11088	EASSAVPTP	COP1	0.9855	More...