DegronMD

Uniprot ID: O75995

Source protein: SAM and SH3 domain-containing protein 3

Source gene: SASH3

Class: DEG_COP1_1

Location: 54:62

E3 ligase: COP1

DEGRON score: 0.9957

ASA_SCORE: 81.6778

COIL: 0.8642

CONS_SCORE: 0.6275

DSS_SCORE: 0.6913

HELIX: 0.1153

FCONS_SCORE: 1.0296

RIG_SCORE: 0.6498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P60H	TCGA-DZ-6131	KIRP	TCGA	EDDSGVPTP	DEG_COP1_1	0.7694
p.P60H	DO20911	KIRP	ICGC	EDDSGVPTP	DEG_COP1_1	0.7694
p.P62Q	DO231018	LUSC	ICGC	EDDSGVPTP	DEG_COP1_1	0.7035
p.P62L	DO222702	MELA	ICGC	EDDSGVPTP	DEG_COP1_1	0.6471
p.P62S	SIDM00789	Colorectal Carcinoma	GDSC	EDDSGVPTP	DEG_COP1_1	0.6752
p.P62S	ACH-000997	Colon/Colorectal Cancer	CCLE	EDDSGVPTP	DEG_COP1_1	0.6752
p.P62S	ACH-001061	Colon/Colorectal Cancer	CCLE	EDDSGVPTP	DEG_COP1_1	0.6752
p.P62S	HCT-15	large_intestine	COSMIC	EDDSGVPTP	DEG_COP1_1	0.6752
p.D64Y	SIDM00168	Head and Neck Carcinoma	GDSC	EDDSGVPTP	DEG_COP1_1	0.2778
p.D64Y	ACH-000549	Head and Neck Cancer	CCLE	EDDSGVPTP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75995	SAM and SH3 domain-containing protein 3	DEG_COP1_1	54:62	EDDSGVPTP	COP1	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons