DegronMD

Uniprot ID: Q14126

Source protein: Desmoglein-2

Source gene: DSG2

Class: DEG_COP1_1

Location: 665:672

E3 ligase: COP1

DEGRON score: 0.9985

ASA_SCORE: 69.0625

COIL: 0.7494

CONS_SCORE: 0.73

DSS_SCORE: 0.5552

HELIX: 0.1049

FCONS_SCORE: 1.0276

RIG_SCORE: 0.766

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D666Y	DO229037	LICA	ICGC	EDKVVPSF	DEG_COP1_1	0.7325
p.E665G	TCGA-HT-A5RB	LGG	TCGA	EDKVVPSF	DEG_COP1_1	0.7199
p.E665G	DO48610	LGG	ICGC	EDKVVPSF	DEG_COP1_1	0.7199
p.P670S	SIDM00966	Ovarian Carcinoma	GDSC	EDKVVPSF	DEG_COP1_1	0.6752
p.P670S	ACH-002182	Ovarian Cancer	CCLE	EDKVVPSF	DEG_COP1_1	0.6752
p.P670S	OVCA433	ovary	COSMIC	EDKVVPSF	DEG_COP1_1	0.6752
p.K667R	TCGA-EE-A2MS	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	0.6126
p.K667R	DO37567	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	0.6126
p.P674S	DO229218	THCA	ICGC	EDKVVPSF	DEG_COP1_1	0.2778
p.D676N	SIDM00425	Ovarian Carcinoma	GDSC	EDKVVPSF	DEG_COP1_1	0.2222
p.D676N	ACH-000663	Ovarian Cancer	CCLE	EDKVVPSF	DEG_COP1_1	0.2222
p.D676N	OVTOKO	ovary	COSMIC	EDKVVPSF	DEG_COP1_1	0.2222
p.Q677K	TCGA-EE-A2M5	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	0.1944
p.Q677K	DO222423	MELA	ICGC	EDKVVPSF	DEG_COP1_1	0.1944
p.Q677K	DO37425	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	0.1944
p.G679V	TCGA-GV-A40G	BLCA	TCGA	EDKVVPSF	DEG_COP1_1	0.1389
p.G679V	DO584	BLCA	ICGC	EDKVVPSF	DEG_COP1_1	0.1389
p.W657L	TCGA-EE-A2GI	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	0.1111
p.W657L	DO37410	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	0.1111
p.P656H	TCGA-VQ-A8P5	STAD	TCGA	EDKVVPSF	DEG_COP1_1	0.0833
p.P656H	DO51763	STAD	ICGC	EDKVVPSF	DEG_COP1_1	0.0833
p.H655Y	TCGA-YD-A9TA	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	0.0556
p.H655Y	DO219503	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	0.0556

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14126	Desmoglein-2	DEG_COP1_1	665:672	EDKVVPSF	COP1	0.9985	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons