DegronMD - Q14126(DSG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D216Y	TCGA-86-8279	LUAD	TCGA	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7325
p.D216Y	DO24140	LUAD	ICGC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7325
p.P1031S	TCGA-AJ-A3EL	UCEC	TCGA	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation altering degron motif	0.5641
p.P1031S	DO41542	UCEC	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation altering degron motif	0.5641
p.D228E	TCGA-E1-A7Z6	LGG	TCGA	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.0833
p.D228E	DO219809	LGG	ICGC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.0833
p.W657L	TCGA-EE-A2GI	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1111
p.W657L	DO37410	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1111
p.Q677K	TCGA-EE-A2M5	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1944
p.Q677K	DO222423	MELA	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1944
p.Q677K	DO37425	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1944
p.K667R	TCGA-EE-A2MS	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.6126
p.K667R	DO37567	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.6126
p.P208L	TCGA-FR-A3R1	SKCM	TCGA	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.1667
p.P208L	DO37991	SKCM	ICGC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.1667
p.G218R	TCGA-FS-A1YY	SKCM	TCGA	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7568
p.G218R	DO37415	SKCM	ICGC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7568
p.K215Q	TCGA-G2-A2ES	BLCA	TCGA	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.5833
p.K215Q	DO785	BLCA	ICGC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.5833
p.G679V	TCGA-GV-A40G	BLCA	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1389
p.G679V	DO584	BLCA	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.1389
p.E665G	TCGA-HT-A5RB	LGG	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.7199
p.E665G	DO48610	LGG	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.7199
p.P656H	TCGA-VQ-A8P5	STAD	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.0833
p.P656H	DO51763	STAD	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.0833
p.H655Y	TCGA-YD-A9TA	SKCM	TCGA	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.0556
p.H655Y	DO219503	SKCM	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.0556
p.L1023F	TCGA-YD-A9TA	SKCM	TCGA	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation altering degron motif	0.6981
p.L1023F	DO219503	SKCM	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation altering degron motif	0.6981
p.S1026G	DO233823	GACA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation altering degron motif	0.5882
p.Q1042H	DO228986	LICA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation rewiring degron network	0.1389
p.D666Y	DO229037	LICA	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.7325
p.A1039S	DO229037	LICA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation rewiring degron network	0.2222
p.A1024G	DO222527	MELA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation altering degron motif	0.754
p.P674S	DO229218	THCA	ICGC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.2778
p.Y212C	DO229213	THCA	ICGC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation blocking phosphorylation signal	0.7222
p.D676N	SIDM00425	Ovarian Carcinoma	GDSC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.2222
p.D676N	ACH-000663	Ovarian Cancer	CCLE	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.2222
p.D676N	OVTOKO	ovary	COSMIC	EDKVVPSF	DEG_COP1_1	665:672	Mutation rewiring degron network	0.2222
p.V1014I	SIDM00211	B-Lymphoblastic Leukemia	GDSC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation rewiring degron network	0.0833
p.V1014I	ACH-002209	Leukemia	CCLE	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation rewiring degron network	0.0833
p.V1014I	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	1023:1035	Mutation rewiring degron network	0.0833
p.P670S	SIDM00966	Ovarian Carcinoma	GDSC	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.6752
p.P670S	ACH-002182	Ovarian Cancer	CCLE	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.6752
p.P670S	OVCA433	ovary	COSMIC	EDKVVPSF	DEG_COP1_1	665:672	Mutation altering degron motif	0.6752
p.T217R	SIDM00316	Glioblastoma	GDSC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7876
p.T217R	ACH-000469	Brain Cancer	CCLE	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7876
p.T217R	YH-13	central nervous system	COSMIC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation altering degron motif	0.7876
p.V225F	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.1667
p.V225F	ACH-000888	Lung Cancer	CCLE	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.1667
p.V225F	NCI-H1793	lung	COSMIC	NKDTGE	DEG_Kelch_Keap1_1	214:219	Mutation rewiring degron network	0.1667

Kaplan plot for DSG2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSG2

UniProt ID: Q14126

Entrez ID: 1829

Protein name: Desmoglein-2 (Cadherin family member 5) (HDGC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSG2 in