DegronMD

Uniprot ID: Q14126

Source protein: Desmoglein-2

Source gene: DSG2

Class: DEG_Kelch_Keap1_1

Location: 214:219

E3 ligase: KEAP1

DEGRON score: 0.9712

ASA_SCORE: 62.2167

COIL: 0.7597

CONS_SCORE: 0.7608

DSS_SCORE: 0.2789

HELIX: 0.0145

FCONS_SCORE: 1.0367

RIG_SCORE: 0.7992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D216Y	TCGA-86-8279	LUAD	TCGA	NKDTGE	DEG_Kelch_Keap1_1	0.7325
p.D216Y	DO24140	LUAD	ICGC	NKDTGE	DEG_Kelch_Keap1_1	0.7325
p.D228E	TCGA-E1-A7Z6	LGG	TCGA	NKDTGE	DEG_Kelch_Keap1_1	0.0833
p.D228E	DO219809	LGG	ICGC	NKDTGE	DEG_Kelch_Keap1_1	0.0833
p.P208L	TCGA-FR-A3R1	SKCM	TCGA	NKDTGE	DEG_Kelch_Keap1_1	0.1667
p.P208L	DO37991	SKCM	ICGC	NKDTGE	DEG_Kelch_Keap1_1	0.1667
p.G218R	TCGA-FS-A1YY	SKCM	TCGA	NKDTGE	DEG_Kelch_Keap1_1	0.7568
p.G218R	DO37415	SKCM	ICGC	NKDTGE	DEG_Kelch_Keap1_1	0.7568
p.K215Q	TCGA-G2-A2ES	BLCA	TCGA	NKDTGE	DEG_Kelch_Keap1_1	0.5833
p.K215Q	DO785	BLCA	ICGC	NKDTGE	DEG_Kelch_Keap1_1	0.5833
p.Y212C	DO229213	THCA	ICGC	NKDTGE	DEG_Kelch_Keap1_1	0.7222
p.T217R	SIDM00316	Glioblastoma	GDSC	NKDTGE	DEG_Kelch_Keap1_1	0.7876
p.T217R	ACH-000469	Brain Cancer	CCLE	NKDTGE	DEG_Kelch_Keap1_1	0.7876
p.T217R	YH-13	central_nervous_system	COSMIC	NKDTGE	DEG_Kelch_Keap1_1	0.7876
p.V225F	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	NKDTGE	DEG_Kelch_Keap1_1	0.1667
p.V225F	ACH-000888	Lung Cancer	CCLE	NKDTGE	DEG_Kelch_Keap1_1	0.1667
p.V225F	NCI-H1793	lung	COSMIC	NKDTGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14126	Desmoglein-2	DEG_Kelch_Keap1_1	214:219	NKDTGE	KEAP1	0.9712	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons