DegronMD

Uniprot ID: Q14126

Source protein: Desmoglein-2

Source gene: DSG2

Class: DEG_ODPH_VHL_1

Location: 1023:1035

E3 ligase: VHL

DEGRON score: 0.9997

ASA_SCORE: 66.8462

COIL: 0.7335

CONS_SCORE: 0.7087

DSS_SCORE: 0.3812

HELIX: 0.0799

FCONS_SCORE: 1.0601

RIG_SCORE: 0.7213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1031S	TCGA-AJ-A3EL	UCEC	TCGA	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.5641
p.P1031S	DO41542	UCEC	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.5641
p.L1023F	TCGA-YD-A9TA	SKCM	TCGA	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.6981
p.L1023F	DO219503	SKCM	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.6981
p.S1026G	DO233823	GACA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.5882
p.Q1042H	DO228986	LICA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.1389
p.A1039S	DO229037	LICA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.2222
p.A1024G	DO222527	MELA	ICGC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.754
p.V1014I	SIDM00211	B-Lymphoblastic Leukemia	GDSC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.0833
p.V1014I	ACH-002209	Leukemia	CCLE	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.0833
p.V1014I	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSSGVQPTLAM	DEG_ODPH_VHL_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14126	Desmoglein-2	DEG_ODPH_VHL_1	1023:1035	LAPSSGVQPTLAM	VHL	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons