DegronMD

Uniprot ID: P08648

Source protein: Integrin alpha-5

Source gene: ITGA5

Class: DEG_COP1_1

Location: 647:655

E3 ligase: COP1

DEGRON score: 0.7831

ASA_SCORE: 55.0111

COIL: 0.6812

CONS_SCORE: 0.7008

DSS_SCORE: 0.0988

HELIX: 0.0652

FCONS_SCORE: 1.3629

RIG_SCORE: 0.8726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P653S	DO227657	COCA	ICGC	EDNICVPDL	DEG_COP1_1	0.6752
p.V652M	DO233850	GACA	ICGC	EDNICVPDL	DEG_COP1_1	0.7208
p.P653T	DO229019	LICA	ICGC	EDNICVPDL	DEG_COP1_1	0.7031
p.E647K	DO220877	MELA	ICGC	EDNICVPDL	DEG_COP1_1	0.7022
p.N649K	DO51102	PRAD	ICGC	EDNICVPDL	DEG_COP1_1	0.5806
p.H665D	SIDM00365	Small Cell Lung Carcinoma	GDSC	EDNICVPDL	DEG_COP1_1	0.0556
p.H665D	ACH-002196	Lung Cancer	CCLE	EDNICVPDL	DEG_COP1_1	0.0556
p.H665D	SBC-1	lung	COSMIC	EDNICVPDL	DEG_COP1_1	0.0556
p.Q663H	SIDM00989	Bladder Carcinoma	GDSC	EDNICVPDL	DEG_COP1_1	0.1111
p.Q663H	ACH-000802	Bladder Cancer	CCLE	EDNICVPDL	DEG_COP1_1	0.1111
p.Q663H	BFTC-905	urinary_tract	COSMIC	EDNICVPDL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08648	Integrin alpha-5	DEG_COP1_1	647:655	EDNICVPDL	COP1	0.7831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons