DegronMD - P08648(ITGA5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P377S	TCGA-06-5416	GBM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.5641
p.P377S	DO10880	GBM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.5641
p.N609Y	TCGA-53-7624	LUAD	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.2222
p.N609Y	DO25058	LUAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.2222
p.L608F	TCGA-A5-A0G2	UCEC	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.25
p.L608F	DO41235	UCEC	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.25
p.F389C	TCGA-AX-A0J0	UCEC	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1389
p.F389C	DO41133	UCEC	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1389
p.P614L	TCGA-BR-6452	STAD	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0833
p.P614L	DO38404	STAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0833
p.L381F	TCGA-D3-A1Q4	SKCM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.587
p.L381F	DO47631	SKCM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.587
p.R391Q	TCGA-D3-A8GQ	SKCM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.0833
p.R391Q	DO229003	COCA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.0833
p.R391Q	DO51246	SKCM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.0833
p.F392V	TCGA-DD-AAE7	LIHC	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.0556
p.F392V	DO52262	LIHC	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.0556
p.D387N	TCGA-EE-A2A2	SKCM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1944
p.D387N	DO37583	SKCM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1944
p.M587I	TCGA-EE-A2MJ	SKCM	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0556
p.M587I	DO38099	SKCM	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0556
p.V367I	TCGA-HU-A4G8	STAD	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1111
p.V367I	DO47819	STAD	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1111
p.A607D	TCGA-IB-7651	PAAD	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.2778
p.A607D	DO46657	PAAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.2778
p.P653S	DO227657	COCA	ICGC	EDNICVPDL	DEG_COP1_1	647:655	Mutation altering degron motif	0.6752
p.R598L	DO234303	ESAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.8428
p.V652M	DO233850	GACA	ICGC	EDNICVPDL	DEG_COP1_1	647:655	Mutation altering degron motif	0.7208
p.D670E	DO228948	LICA	ICGC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.1111
p.P653T	DO229019	LICA	ICGC	EDNICVPDL	DEG_COP1_1	647:655	Mutation altering degron motif	0.7031
p.A373D	DO229015	LICA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.2778
p.A373D	DO229006	LICA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.2778
p.E647K	DO220877	MELA	ICGC	EDNICVPDL	DEG_COP1_1	647:655	Mutation altering degron motif	0.7022
p.D613N	DO222702	MELA	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.1111
p.A373V	DO232224	PBCA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.2778
p.N649K	DO51102	PRAD	ICGC	EDNICVPDL	DEG_COP1_1	647:655	Mutation altering degron motif	0.5806
p.T382A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.7139
p.T382A	ACH-000960	Leukemia	CCLE	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.7139
p.T382A	REH	haematopoietic and lymphoid tissue	COSMIC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation altering degron motif	0.7139
p.S602W	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6763
p.S602W	ACH-000766	Lung Cancer	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6763
p.S602W	NCI-H1648	lung	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6763
p.S602L	SIDM00057	Neuroblastoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6556
p.S602L	ACH-000676	Brain Cancer	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6556
p.S602L	ACH-002389	Neuroblastoma	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6556
p.S602L	ACN	autonomic ganglia	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6556
p.E594K	SIDM00596	Endometrial Carcinoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.25
p.E594K	ACH-001517	Endometrial/Uterine Cancer	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.25
p.E594K	HEC-1	endometrium	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.25
p.H665D	SIDM00365	Small Cell Lung Carcinoma	GDSC	EDNICVPDL	DEG_COP1_1	647:655	Mutation rewiring degron network	0.0556
p.H665D	SIDM00365	Small Cell Lung Carcinoma	GDSC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.25
p.H665D	ACH-002196	Lung Cancer	CCLE	EDNICVPDL	DEG_COP1_1	647:655	Mutation rewiring degron network	0.0556
p.H665D	ACH-002196	Lung Cancer	CCLE	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.25
p.H665D	SBC-1	lung	COSMIC	EDNICVPDL	DEG_COP1_1	647:655	Mutation rewiring degron network	0.0556
p.H665D	SBC-1	lung	COSMIC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.25
p.Q615K	SIDM00254	Neuroblastoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0556
p.Q615K	SIDM00930	Osteosarcoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0556
p.Q615K	SIDM01752	Pancreatic Carcinoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation rewiring degron network	0.0556
p.Q663H	SIDM00989	Bladder Carcinoma	GDSC	EDNICVPDL	DEG_COP1_1	647:655	Mutation rewiring degron network	0.1111
p.Q663H	SIDM00989	Bladder Carcinoma	GDSC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.3056
p.Q663H	ACH-000802	Bladder Cancer	CCLE	EDNICVPDL	DEG_COP1_1	647:655	Mutation rewiring degron network	0.1111
p.Q663H	ACH-000802	Bladder Cancer	CCLE	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.3056
p.Q663H	BFTC-905	urinary tract	COSMIC	EDNICVPDL	DEG_COP1_1	647:655	Mutation rewiring degron network	0.1111
p.Q663H	BFTC-905	urinary tract	COSMIC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.3056
p.D387H	SIDM00241	Breast Carcinoma	GDSC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1944
p.D387H	ACH-000928	Endometrial/Uterine Cancer	CCLE	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1944
p.D387H	ACH-002179	Breast Cancer	CCLE	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1944
p.D387H	OCUB-M	breast	COSMIC	IEPTPTLT	DEG_SCF_FBW7_1	375:382	Mutation rewiring degron network	0.1944
p.V666M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.2222
p.V666M	ACH-001127	Leukemia	CCLE	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.2222
p.V666M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LEVFGE	LIG_APCC_ABBA_1	657:662	Mutation rewiring degron network	0.2222
p.D599Y	SIDM00145	T-Lymphoblastic Leukemia	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6214
p.D599Y	ACH-001127	Leukemia	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6214
p.D599Y	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	597:605	Mutation altering degron motif	0.6214

Kaplan plot for ITGA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA5

UniProt ID: P08648

Entrez ID: 3678

Protein name: Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA5 in