DegronMD

Uniprot ID: P08648

Source protein: Integrin alpha-5

Source gene: ITGA5

Class: DEG_APCC_DBOX_1

Location: 597:605

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.658

ASA_SCORE: 52.8111

COIL: 0.6278

CONS_SCORE: 0.6421

DSS_SCORE: 0.2108

HELIX: 0.0572

FCONS_SCORE: 1.421

RIG_SCORE: 0.7804

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N609Y	TCGA-53-7624	LUAD	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	0.2222
p.N609Y	DO25058	LUAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.2222
p.L608F	TCGA-A5-A0G2	UCEC	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	0.25
p.L608F	DO41235	UCEC	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.25
p.P614L	TCGA-BR-6452	STAD	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	0.0833
p.P614L	DO38404	STAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.0833
p.M587I	TCGA-EE-A2MJ	SKCM	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	0.0556
p.M587I	DO38099	SKCM	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.0556
p.A607D	TCGA-IB-7651	PAAD	TCGA	FRDKLSPIH	DEG_APCC_DBOX_1	0.2778
p.A607D	DO46657	PAAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.2778
p.R598L	DO234303	ESAD	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.8428
p.D613N	DO222702	MELA	ICGC	FRDKLSPIH	DEG_APCC_DBOX_1	0.1111
p.S602W	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.6763
p.S602W	ACH-000766	Lung Cancer	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	0.6763
p.S602W	NCI-H1648	lung	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	0.6763
p.S602L	SIDM00057	Neuroblastoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.6556
p.S602L	ACH-000676	Brain Cancer	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	0.6556
p.S602L	ACH-002389	Neuroblastoma	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	0.6556
p.S602L	ACN	autonomic_ganglia	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	0.6556
p.E594K	SIDM00596	Endometrial Carcinoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.25
p.E594K	ACH-001517	Endometrial/Uterine Cancer	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	0.25
p.E594K	HEC-1	endometrium	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	0.25
p.Q615K	SIDM00254	Neuroblastoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.0556
p.Q615K	SIDM00930	Osteosarcoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.0556
p.Q615K	SIDM01752	Pancreatic Carcinoma	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.0556
p.D599Y	SIDM00145	T-Lymphoblastic Leukemia	GDSC	FRDKLSPIH	DEG_APCC_DBOX_1	0.6214
p.D599Y	ACH-001127	Leukemia	CCLE	FRDKLSPIH	DEG_APCC_DBOX_1	0.6214
p.D599Y	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	FRDKLSPIH	DEG_APCC_DBOX_1	0.6214

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRDKLSPIH

Degron related mutations and impact score

Drug responses associated with ITGA5 mutations

All proteins holding degron of FRDKLSPIH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08648	Integrin alpha-5	DEG_APCC_DBOX_1	597:605	FRDKLSPIH	APC,CDC20,FZR1	0.658	More...