DegronMD

Uniprot ID: P08648

Source protein: Integrin alpha-5

Source gene: ITGA5

Class: LIG_APCC_ABBA_1

Location: 657:662

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6046

ASA_SCORE: 50.5

COIL: 0.3652

CONS_SCORE: 0.4064

DSS_SCORE: 0.1108

HELIX: 0.0193

FCONS_SCORE: 0.6932

RIG_SCORE: 0.8411

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q663H	SIDM00989	Bladder Carcinoma	GDSC	LEVFGE	LIG_APCC_ABBA_1	0.3056
p.Q663H	ACH-000802	Bladder Cancer	CCLE	LEVFGE	LIG_APCC_ABBA_1	0.3056
p.Q663H	BFTC-905	urinary_tract	COSMIC	LEVFGE	LIG_APCC_ABBA_1	0.3056
p.H665D	SIDM00365	Small Cell Lung Carcinoma	GDSC	LEVFGE	LIG_APCC_ABBA_1	0.25
p.H665D	ACH-002196	Lung Cancer	CCLE	LEVFGE	LIG_APCC_ABBA_1	0.25
p.H665D	SBC-1	lung	COSMIC	LEVFGE	LIG_APCC_ABBA_1	0.25
p.V666M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LEVFGE	LIG_APCC_ABBA_1	0.2222
p.V666M	ACH-001127	Leukemia	CCLE	LEVFGE	LIG_APCC_ABBA_1	0.2222
p.V666M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LEVFGE	LIG_APCC_ABBA_1	0.2222
p.D670E	DO228948	LICA	ICGC	LEVFGE	LIG_APCC_ABBA_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08648	Integrin alpha-5	LIG_APCC_ABBA_1	657:662	LEVFGE	APC,CDC20,FZR1	0.6046	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons