DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LEVFGE
Uniprot ID:
P08648
Source protein:
Integrin alpha-5
Source gene:
ITGA5
Class:
LIG_APCC_ABBA_1
Location:
657:662
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6046
ASA_SCORE:
50.5
COIL:
0.3652
CONS_SCORE:
0.4064
DSS_SCORE:
0.1108
HELIX:
0.0193
FCONS_SCORE:
0.6932
RIG_SCORE:
0.8411
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D670E
DO228948
LICA
ICGC
LEVFGE
LIG_APCC_ABBA_1
0.1111
p.H665D
SIDM00365
Small Cell Lung Carcinoma
GDSC
LEVFGE
LIG_APCC_ABBA_1
0.25
p.H665D
ACH-002196
Lung Cancer
CCLE
LEVFGE
LIG_APCC_ABBA_1
0.25
p.H665D
SBC-1
lung
COSMIC
LEVFGE
LIG_APCC_ABBA_1
0.25
p.Q663H
SIDM00989
Bladder Carcinoma
GDSC
LEVFGE
LIG_APCC_ABBA_1
0.3056
p.Q663H
ACH-000802
Bladder Cancer
CCLE
LEVFGE
LIG_APCC_ABBA_1
0.3056
p.Q663H
BFTC-905
urinary_tract
COSMIC
LEVFGE
LIG_APCC_ABBA_1
0.3056
p.V666M
SIDM00145
T-Lymphoblastic Leukemia
GDSC
LEVFGE
LIG_APCC_ABBA_1
0.2222
p.V666M
ACH-001127
Leukemia
CCLE
LEVFGE
LIG_APCC_ABBA_1
0.2222
p.V666M
MOLT-4
haematopoietic_and_lymphoid_tissue
COSMIC
LEVFGE
LIG_APCC_ABBA_1
0.2222
Drug responses associated with ITGA5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LEVFGE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P08648
Integrin alpha-5
LIG_APCC_ABBA_1
657:662
LEVFGE
APC,CDC20,FZR1
0.6046
More...