DegronMD

Uniprot ID: P08648

Source protein: Integrin alpha-5

Source gene: ITGA5

Class: DEG_SCF_FBW7_1

Location: 375:382

E3 ligase: FBXW7

DEGRON score: 0.6853

ASA_SCORE: 67.825

COIL: 0.5186

CONS_SCORE: 0.3815

DSS_SCORE: 0.4759

HELIX: 0.0126

FCONS_SCORE: 0.6346

RIG_SCORE: 0.7293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P377S	TCGA-06-5416	GBM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.5641
p.P377S	DO10880	GBM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.5641
p.F389C	TCGA-AX-A0J0	UCEC	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.1389
p.F389C	DO41133	UCEC	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.1389
p.L381F	TCGA-D3-A1Q4	SKCM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.587
p.L381F	DO47631	SKCM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.587
p.R391Q	TCGA-D3-A8GQ	SKCM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.0833
p.R391Q	DO229003	COCA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.0833
p.R391Q	DO51246	SKCM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.0833
p.F392V	TCGA-DD-AAE7	LIHC	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.0556
p.F392V	DO52262	LIHC	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.0556
p.D387N	TCGA-EE-A2A2	SKCM	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.1944
p.D387N	DO37583	SKCM	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.1944
p.V367I	TCGA-HU-A4G8	STAD	TCGA	IEPTPTLT	DEG_SCF_FBW7_1	0.1111
p.V367I	DO47819	STAD	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.1111
p.A373D	DO229015	LICA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.2778
p.A373D	DO229006	LICA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.2778
p.A373V	DO232224	PBCA	ICGC	IEPTPTLT	DEG_SCF_FBW7_1	0.2778
p.T382A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IEPTPTLT	DEG_SCF_FBW7_1	0.7139
p.T382A	ACH-000960	Leukemia	CCLE	IEPTPTLT	DEG_SCF_FBW7_1	0.7139
p.T382A	REH	haematopoietic_and_lymphoid_tissue	COSMIC	IEPTPTLT	DEG_SCF_FBW7_1	0.7139
p.D387H	SIDM00241	Breast Carcinoma	GDSC	IEPTPTLT	DEG_SCF_FBW7_1	0.1944
p.D387H	ACH-000928	Endometrial/Uterine Cancer	CCLE	IEPTPTLT	DEG_SCF_FBW7_1	0.1944
p.D387H	ACH-002179	Breast Cancer	CCLE	IEPTPTLT	DEG_SCF_FBW7_1	0.1944
p.D387H	OCUB-M	breast	COSMIC	IEPTPTLT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08648	Integrin alpha-5	DEG_SCF_FBW7_1	375:382	IEPTPTLT	FBXW7	0.6853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons