DegronMD

Uniprot ID: Q5JVS0

Source protein: Intracellular hyaluronan-binding protein 4

Source gene: HABP4

Class: DEG_COP1_1

Location: 270:280

E3 ligase: COP1

DEGRON score: 0.8039

ASA_SCORE: 100.4182

COIL: 0.8177

CONS_SCORE: 0.549

DSS_SCORE: 0.8038

HELIX: 0.1637

FCONS_SCORE: 0.9277

RIG_SCORE: 0.6457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S265Y	TCGA-FS-A1ZJ	SKCM	TCGA	EEESPAKVPEL	DEG_COP1_1	0.1944
p.S265Y	DO37956	SKCM	ICGC	EEESPAKVPEL	DEG_COP1_1	0.1944
p.R264H	DO683	BLCA	ICGC	EEESPAKVPEL	DEG_COP1_1	0.1667
p.G272E	DO49950	CESC	ICGC	EEESPAKVPEL	DEG_COP1_1	0.7199
p.G272E	NCI-H510A	lung	COSMIC	EEESPAKVPEL	DEG_COP1_1	0.7199
p.E264D	DO229051	LICA	ICGC	EEESPAKVPEL	DEG_COP1_1	0.1667
p.P260H	LNCaP-Clone-FGC	prostate	COSMIC	EEESPAKVPEL	DEG_COP1_1	0.0556
p.R261C	HCC2998	large_intestine	COSMIC	EEESPAKVPEL	DEG_COP1_1	0.0833
p.R274W	OSC-20	upper_aerodigestive_tract	COSMIC	EEESPAKVPEL	DEG_COP1_1	0.8634
p.R274W	NOS-1	bone	COSMIC	EEESPAKVPEL	DEG_COP1_1	0.8634
p.R271Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	EEESPAKVPEL	DEG_COP1_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JVS0	Intracellular hyaluronan-binding protein 4	DEG_COP1_1	270:280	EEESPAKVPEL	COP1	0.8039	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons