DegronMD

Uniprot ID: Q9Y6N8

Source protein: Cadherin-10

Source gene: CDH10

Class: DEG_COP1_1

Location: 162:172

E3 ligase: COP1

DEGRON score: 0.731

ASA_SCORE: 56.9273

COIL: 0.3913

CONS_SCORE: 0.7474

DSS_SCORE: 0.4186

HELIX: 0.0098

FCONS_SCORE: 0.9203

RIG_SCORE: 0.8015

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V174L	TCGA-05-4398	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.2778
p.V174L	DO25847	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.2778
p.S173P	TCGA-25-1316	OV	TCGA	EEIYTASVPEM	DEG_COP1_1	0.3056
p.S173P	DO30600	OV	ICGC	EEIYTASVPEM	DEG_COP1_1	0.3056
p.E171K	TCGA-49-4512	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.7022
p.E171K	DO23735	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.7022
p.E171K	SIDM01301	Esophageal Carcinoma	GDSC	EEIYTASVPEM	DEG_COP1_1	0.7022
p.T177N	TCGA-55-8302	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.1944
p.T177N	DO45312	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.1944
p.V175L	TCGA-55-A4DF	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.25
p.V175L	DO45318	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.25
p.G176V	TCGA-73-4658	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.2222
p.G176V	DO23663	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.2222
p.G176C	TCGA-A5-A0G2	UCEC	TCGA	EEIYTASVPEM	DEG_COP1_1	0.2222
p.G176C	TCGA-VQ-A924	STAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.2222
p.G176C	DO51795	STAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.2222
p.G176C	DO41235	UCEC	ICGC	EEIYTASVPEM	DEG_COP1_1	0.2222
p.S168I	TCGA-AX-A2HD	UCEC	TCGA	EEIYTASVPEM	DEG_COP1_1	0.623
p.S168I	DO23525	LIRI	ICGC	EEIYTASVPEM	DEG_COP1_1	0.623
p.S168I	DO42608	UCEC	ICGC	EEIYTASVPEM	DEG_COP1_1	0.623
p.V174D	TCGA-CD-8529	STAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.2778
p.V174D	DO47753	STAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.2778
p.D152Y	TCGA-CR-7402	HNSC	TCGA	EEIYTASVPEM	DEG_COP1_1	0.0556
p.D152Y	DO15727	HNSC	ICGC	EEIYTASVPEM	DEG_COP1_1	0.0556
p.P170S	TCGA-D1-A103	UCEC	TCGA	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	TCGA-DA-A1IC	SKCM	TCGA	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	DO37430	SKCM	ICGC	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	DO42312	UCEC	ICGC	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	SIDM00003	Melanoma	GDSC	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	ACH-000884	Skin Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	ACH-002159	Skin Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	0.6752
p.P170S	M14	skin	COSMIC	EEIYTASVPEM	DEG_COP1_1	0.6752
p.D152N	TCGA-EE-A183	SKCM	TCGA	EEIYTASVPEM	DEG_COP1_1	0.0556
p.D152N	DO37715	SKCM	ICGC	EEIYTASVPEM	DEG_COP1_1	0.0556
p.D155Y	TCGA-MP-A4TK	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	0.1389
p.D155Y	DO45384	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	0.1389
p.V182G	TCGA-NC-A5HT	LUSC	TCGA	EEIYTASVPEM	DEG_COP1_1	0.0556
p.V182G	DO219205	LUSC	ICGC	EEIYTASVPEM	DEG_COP1_1	0.0556
p.P170L	TCGA-QQ-A5VD	SARC	TCGA	EEIYTASVPEM	DEG_COP1_1	0.7582
p.P170L	DO220252	SARC	ICGC	EEIYTASVPEM	DEG_COP1_1	0.7582
p.S178F	TCGA-W3-AA1O	SKCM	TCGA	EEIYTASVPEM	DEG_COP1_1	0.1667
p.S178F	DO51274	SKCM	ICGC	EEIYTASVPEM	DEG_COP1_1	0.1667
p.I153V	DO225028	BRCA	ICGC	EEIYTASVPEM	DEG_COP1_1	0.0833
p.E163Q	DO218173	BRCA	ICGC	EEIYTASVPEM	DEG_COP1_1	0.6744
p.V180L	DO233235	GACA	ICGC	EEIYTASVPEM	DEG_COP1_1	0.1111
p.P158S	SIDM00683	Prostate Carcinoma	GDSC	EEIYTASVPEM	DEG_COP1_1	0.2222
p.P170H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	EEIYTASVPEM	DEG_COP1_1	0.7694
p.P170H	ACH-000843	Lung Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	0.7694
p.P170H	HARA	lung	COSMIC	EEIYTASVPEM	DEG_COP1_1	0.7694
p.S168R	ACH-001295	Eye Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	0.6316
p.T177P	ACH-001656	Leukemia	CCLE	EEIYTASVPEM	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EEIYTASVPEM

Degron related mutations and impact score

Drug responses associated with CDH10 mutations

All proteins holding degron of EEIYTASVPEM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N8	Cadherin-10	DEG_COP1_1	162:172	EEIYTASVPEM	COP1	0.731	More...