DegronMD - Q9Y6N8(CDH10)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V174L	TCGA-05-4398	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2778
p.V174L	DO25847	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2778
p.F492L	TCGA-06-5416	GBM	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6981
p.F492L	TCGA-55-7574	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6981
p.F492L	TCGA-CA-6718	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6981
p.F492L	DO7801	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6981
p.F492L	DO10880	GBM	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6981
p.F492L	DO23986	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6981
p.S173P	TCGA-25-1316	OV	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.3056
p.S173P	DO30600	OV	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.3056
p.E171K	TCGA-49-4512	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7022
p.E171K	DO23735	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7022
p.E171K	SIDM01301	Esophageal Carcinoma	GDSC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7022
p.T177N	TCGA-55-8302	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1944
p.T177N	DO45312	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1944
p.V175L	TCGA-55-A4DF	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.25
p.V175L	DO45318	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.25
p.D484Y	TCGA-55-A4DG	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.D484Y	DO26337	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.G504W	TCGA-5N-A9KM	BLCA	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.G504W	TCGA-95-7039	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.G504W	DO223517	BLCA	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.G504W	DO23907	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.Q488K	TCGA-60-2709	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.3056
p.Q488K	DO27096	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.3056
p.A501V	TCGA-62-8398	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1389
p.A501V	DO45345	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1389
p.G176V	TCGA-73-4658	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.G176V	DO23663	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.G504V	TCGA-77-A5G3	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.G504V	TCGA-78-8662	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.G504V	DO45346	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.G504V	DO45456	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.V491L	TCGA-85-8353	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.5654
p.V491L	DO45530	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.5654
p.G176C	TCGA-A5-A0G2	UCEC	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.G176C	TCGA-VQ-A924	STAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.G176C	DO51795	STAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.G176C	DO41235	UCEC	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.A486S	TCGA-A6-5659	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.A486S	DO9860	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.S168I	TCGA-AX-A2HD	UCEC	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.623
p.S168I	DO23525	LIRI	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.623
p.S168I	DO42608	UCEC	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.623
p.L480V	TCGA-AZ-4315	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.L480V	TCGA-D3-A2JO	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.L480V	DO8842	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.L480V	DO47619	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.T495N	TCGA-BA-4074	HNSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.3056
p.T495N	DO14710	HNSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.3056
p.D481V	TCGA-BA-4074	HNSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.D481V	DO14710	HNSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.D484N	TCGA-BF-AAP7	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.D484N	DO219472	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.V174D	TCGA-CD-8529	STAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2778
p.V174D	DO47753	STAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2778
p.D152Y	TCGA-CR-7402	HNSC	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0556
p.D152Y	DO15727	HNSC	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0556
p.P170S	TCGA-D1-A103	UCEC	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	TCGA-DA-A1IC	SKCM	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	DO37430	SKCM	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	DO42312	UCEC	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	SIDM00003	Melanoma	GDSC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	ACH-000884	Skin Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	ACH-002159	Skin Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.P170S	M14	skin	COSMIC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6752
p.L480F	TCGA-D1-A16D	UCEC	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.L480F	DO223069	ESCA	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.L480F	DO42217	UCEC	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.E499K	TCGA-D3-A8GQ	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.E499K	DO51246	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.D152N	TCGA-EE-A183	SKCM	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0556
p.D152N	DO37715	SKCM	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0556
p.P487L	TCGA-EE-A3JA	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.2778
p.P487L	DO222843	MELA	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.2778
p.P487L	DO47625	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.2778
p.D155Y	TCGA-MP-A4TK	LUAD	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1389
p.D155Y	DO45384	LUAD	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1389
p.V182G	TCGA-NC-A5HT	LUSC	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0556
p.V182G	DO219205	LUSC	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0556
p.P170L	TCGA-QQ-A5VD	SARC	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7582
p.P170L	DO220252	SARC	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7582
p.S178F	TCGA-W3-AA1O	SKCM	TCGA	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1667
p.S178F	DO51274	SKCM	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1667
p.I153V	DO225028	BRCA	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.0833
p.E163Q	DO218173	BRCA	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6744
p.I479M	DO8264	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0556
p.V180L	DO233235	GACA	ICGC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1111
p.D484V	DO233644	GACA	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.D481Y	DO50907	LICA	ICGC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.E499A	SIDM01290	Esophageal Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.P158S	SIDM00683	Prostate Carcinoma	GDSC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.2222
p.D494N	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6932
p.D494N	SIDM01662	Plasma Cell Myeloma	GDSC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6932
p.D494N	TE-11	oesophagus	COSMIC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.6932
p.V497L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.V497L	ACH-001363	Lung Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.V497L	NCI-H2135	lung	COSMIC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.P170H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7694
p.P170H	ACH-000843	Lung Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7694
p.P170H	HARA	lung	COSMIC	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.7694
p.D484E	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.D484E	ACH-000395	Lung Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.D484E	NCI-H520	lung	COSMIC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.R502K	SIDM00596	Endometrial Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.R502K	ACH-000941	Endometrial/Uterine Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.R502K	ACH-000954	Endometrial/Uterine Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.R502K	ACH-001517	Endometrial/Uterine Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.R502K	HEC-1	endometrium	COSMIC	FAVFYD	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.S168R	ACH-001295	Eye Cancer	CCLE	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation altering degron motif	0.6316
p.T177P	ACH-001656	Leukemia	CCLE	EEIYTASVPEM	DEG_COP1_1	162:172	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH10

UniProt ID: Q9Y6N8

Entrez ID: 1008

Protein name: Cadherin-10 (T2-cadherin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH10 in