DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FAVFYD
Uniprot ID:
Q9Y6N8
Source protein:
Cadherin-10
Source gene:
CDH10
Class:
LIG_APCC_ABBA_1
Location:
489:494
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6381
ASA_SCORE:
68.6833
COIL:
0.6198
CONS_SCORE:
0.6619
DSS_SCORE:
0.1059
HELIX:
0.0753
FCONS_SCORE:
0.8251
RIG_SCORE:
0.9625
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F492L
TCGA-06-5416
GBM
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.6981
p.F492L
TCGA-55-7574
LUAD
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.6981
p.F492L
TCGA-CA-6718
COAD
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.6981
p.F492L
DO7801
COAD
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.6981
p.F492L
DO10880
GBM
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.6981
p.F492L
DO23986
LUAD
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.6981
p.D494N
SIDM00348
Esophageal Squamous Cell Carcinoma
GDSC
FAVFYD
LIG_APCC_ABBA_1
0.6932
p.D494N
SIDM01662
Plasma Cell Myeloma
GDSC
FAVFYD
LIG_APCC_ABBA_1
0.6932
p.D494N
TE-11
oesophagus
COSMIC
FAVFYD
LIG_APCC_ABBA_1
0.6932
p.V491L
TCGA-85-8353
LUSC
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.5654
p.V491L
DO45530
LUSC
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.5654
p.Q488K
TCGA-60-2709
LUSC
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.3056
p.Q488K
DO27096
LUSC
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.3056
p.T495N
TCGA-BA-4074
HNSC
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.3056
p.T495N
DO14710
HNSC
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.3056
p.P487L
TCGA-EE-A3JA
SKCM
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.2778
p.P487L
DO222843
MELA
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.2778
p.P487L
DO47625
SKCM
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.2778
p.A486S
TCGA-A6-5659
COAD
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.25
p.A486S
DO9860
COAD
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.25
p.V497L
SIDM00700
Non-Small Cell Lung Carcinoma
GDSC
FAVFYD
LIG_APCC_ABBA_1
0.25
p.V497L
ACH-001363
Lung Cancer
CCLE
FAVFYD
LIG_APCC_ABBA_1
0.25
p.V497L
NCI-H2135
lung
COSMIC
FAVFYD
LIG_APCC_ABBA_1
0.25
p.D484Y
TCGA-55-A4DG
LUAD
TCGA
FAVFYD
LIG_APCC_ABBA_1
0.1944
p.D484Y
DO26337
LUAD
ICGC
FAVFYD
LIG_APCC_ABBA_1
0.1944
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Drug responses associated with CDH10 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of FAVFYD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y6N8
Cadherin-10
LIG_APCC_ABBA_1
489:494
FAVFYD
APC,CDC20,FZR1
0.6381
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