DegronMD

Uniprot ID: Q9Y6N8

Source protein: Cadherin-10

Source gene: CDH10

Class: LIG_APCC_ABBA_1

Location: 489:494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6381

ASA_SCORE: 68.6833

COIL: 0.6198

CONS_SCORE: 0.6619

DSS_SCORE: 0.1059

HELIX: 0.0753

FCONS_SCORE: 0.8251

RIG_SCORE: 0.9625

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F492L	TCGA-06-5416	GBM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	TCGA-55-7574	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	TCGA-CA-6718	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	DO7801	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	DO10880	GBM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	DO23986	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.D484Y	TCGA-55-A4DG	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D484Y	DO26337	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.G504W	TCGA-5N-A9KM	BLCA	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.G504W	TCGA-95-7039	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.G504W	DO223517	BLCA	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.G504W	DO23907	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.Q488K	TCGA-60-2709	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.Q488K	DO27096	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.A501V	TCGA-62-8398	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.1389
p.A501V	DO45345	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1389
p.G504V	TCGA-77-A5G3	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.G504V	TCGA-78-8662	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.G504V	DO45346	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.G504V	DO45456	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.V491L	TCGA-85-8353	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.5654
p.V491L	DO45530	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.5654
p.A486S	TCGA-A6-5659	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.25
p.A486S	DO9860	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.25
p.L480V	TCGA-AZ-4315	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.L480V	TCGA-D3-A2JO	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.L480V	DO8842	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.L480V	DO47619	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.T495N	TCGA-BA-4074	HNSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.T495N	DO14710	HNSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.D481V	TCGA-BA-4074	HNSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.D481V	DO14710	HNSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.D484N	TCGA-BF-AAP7	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D484N	DO219472	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.L480F	TCGA-D1-A16D	UCEC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.L480F	DO223069	ESCA	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.L480F	DO42217	UCEC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0833
p.E499K	TCGA-D3-A8GQ	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.E499K	DO51246	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.P487L	TCGA-EE-A3JA	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.2778
p.P487L	DO222843	MELA	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.2778
p.P487L	DO47625	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.2778
p.I479M	DO8264	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.0556
p.D484V	DO233644	GACA	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D481Y	DO50907	LICA	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.E499A	SIDM01290	Esophageal Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D494N	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.6932
p.D494N	SIDM01662	Plasma Cell Myeloma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.6932
p.D494N	TE-11	oesophagus	COSMIC	FAVFYD	LIG_APCC_ABBA_1	0.6932
p.V497L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.25
p.V497L	ACH-001363	Lung Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	0.25
p.V497L	NCI-H2135	lung	COSMIC	FAVFYD	LIG_APCC_ABBA_1	0.25
p.D484E	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D484E	ACH-000395	Lung Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D484E	NCI-H520	lung	COSMIC	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.R502K	SIDM00596	Endometrial Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.R502K	ACH-000941	Endometrial/Uterine Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.R502K	ACH-000954	Endometrial/Uterine Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.R502K	ACH-001517	Endometrial/Uterine Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	0.1111
p.R502K	HEC-1	endometrium	COSMIC	FAVFYD	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FAVFYD

Degron related mutations and impact score

Drug responses associated with CDH10 mutations

All proteins holding degron of FAVFYD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N8	Cadherin-10	LIG_APCC_ABBA_1	489:494	FAVFYD	APC,CDC20,FZR1	0.6381	More...