DegronMD

Uniprot ID: Q9Y6N8

Source protein: Cadherin-10

Source gene: CDH10

Class: LIG_APCC_ABBA_1

Location: 489:494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6381

ASA_SCORE: 68.6833

COIL: 0.6198

CONS_SCORE: 0.6619

DSS_SCORE: 0.1059

HELIX: 0.0753

FCONS_SCORE: 0.8251

RIG_SCORE: 0.9625

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F492L	TCGA-06-5416	GBM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	TCGA-55-7574	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	TCGA-CA-6718	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	DO7801	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	DO10880	GBM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.F492L	DO23986	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.6981
p.D494N	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.6932
p.D494N	SIDM01662	Plasma Cell Myeloma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.6932
p.D494N	TE-11	oesophagus	COSMIC	FAVFYD	LIG_APCC_ABBA_1	0.6932
p.V491L	TCGA-85-8353	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.5654
p.V491L	DO45530	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.5654
p.Q488K	TCGA-60-2709	LUSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.Q488K	DO27096	LUSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.T495N	TCGA-BA-4074	HNSC	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.T495N	DO14710	HNSC	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.3056
p.P487L	TCGA-EE-A3JA	SKCM	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.2778
p.P487L	DO222843	MELA	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.2778
p.P487L	DO47625	SKCM	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.2778
p.A486S	TCGA-A6-5659	COAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.25
p.A486S	DO9860	COAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.25
p.V497L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	FAVFYD	LIG_APCC_ABBA_1	0.25
p.V497L	ACH-001363	Lung Cancer	CCLE	FAVFYD	LIG_APCC_ABBA_1	0.25
p.V497L	NCI-H2135	lung	COSMIC	FAVFYD	LIG_APCC_ABBA_1	0.25
p.D484Y	TCGA-55-A4DG	LUAD	TCGA	FAVFYD	LIG_APCC_ABBA_1	0.1944
p.D484Y	DO26337	LUAD	ICGC	FAVFYD	LIG_APCC_ABBA_1	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N8	Cadherin-10	LIG_APCC_ABBA_1	489:494	FAVFYD	APC,CDC20,FZR1	0.6381	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons