DegronMD

Uniprot ID: P15036

Source protein: Protein C-ets-2

Source gene: ETS2

Class: DEG_COP1_1

Location: 45:56

E3 ligase: COP1

DEGRON score: 0.8876

ASA_SCORE: 82.3667

COIL: 0.7388

CONS_SCORE: 0.417

DSS_SCORE: 0.4552

HELIX: 0.2035

FCONS_SCORE: 1.1336

RIG_SCORE: 0.7515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S42F	TCGA-EE-A29E	SKCM	TCGA	EEQTLQEVPTGL	DEG_COP1_1	0.25
p.S42F	DO37831	SKCM	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.25
p.P41S	TCGA-EE-A29R	SKCM	TCGA	EEQTLQEVPTGL	DEG_COP1_1	0.2222
p.P41S	DO37448	SKCM	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.2222
p.L43V	TCGA-Q1-A73O	CESC	TCGA	EEQTLQEVPTGL	DEG_COP1_1	0.2778
p.L43V	DO51612	CESC	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.2778
p.E51D	DO222762	COCA	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.5647
p.E46G	DO50453	ESAD	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.6087
p.V39A	DO228414	MALY	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.1667
p.A64T	DO228138	PBCA	ICGC	EEQTLQEVPTGL	DEG_COP1_1	0.1111
p.N65K	SIDM00993	Plasma Cell Myeloma	GDSC	EEQTLQEVPTGL	DEG_COP1_1	0.0833
p.N65K	ACH-000838	Myeloma	CCLE	EEQTLQEVPTGL	DEG_COP1_1	0.0833
p.N65K	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	EEQTLQEVPTGL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15036	Protein C-ets-2	DEG_COP1_1	45:56	EEQTLQEVPTGL	COP1	0.8876	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons