DegronMD - P15036(ETS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S321F	TCGA-05-4249	LUAD	TCGA	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation blocking phosphorylation signal	0.5
p.S321F	DO23891	LUAD	ICGC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation blocking phosphorylation signal	0.5
p.S42F	TCGA-EE-A29E	SKCM	TCGA	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.25
p.S42F	DO37831	SKCM	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.25
p.P41S	TCGA-EE-A29R	SKCM	TCGA	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.2222
p.P41S	DO37448	SKCM	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.2222
p.P309H	TCGA-EE-A29X	SKCM	TCGA	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.7694
p.P309H	DO37595	SKCM	ICGC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.7694
p.L43V	TCGA-Q1-A73O	CESC	TCGA	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.2778
p.L43V	DO51612	CESC	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.2778
p.P309S	TCGA-W3-AA1V	SKCM	TCGA	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.6752
p.P309S	DO51276	SKCM	ICGC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.6752
p.E51D	DO222762	COCA	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation altering degron motif	0.5647
p.E46G	DO50453	ESAD	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation altering degron motif	0.6087
p.R307Q	DO233801	GACA	ICGC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.6218
p.V39A	DO228414	MALY	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.1667
p.C318R	DO222395	MELA	ICGC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation rewiring degron network	0.1389
p.A64T	DO228138	PBCA	ICGC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.1111
p.N65K	SIDM00993	Plasma Cell Myeloma	GDSC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.0833
p.N65K	ACH-000838	Myeloma	CCLE	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.0833
p.N65K	AMO-1	haematopoietic and lymphoid tissue	COSMIC	EEQTLQEVPTGL	DEG_COP1_1	45:56	Mutation rewiring degron network	0.0833
p.F311L	SIDM00057	Neuroblastoma	GDSC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.587
p.F311L	ACH-002389	Neuroblastoma	CCLE	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.587
p.F311L	ACN	autonomic ganglia	COSMIC	SSLLDVQRVPSF	DEG_COP1_1	300:311	Mutation altering degron motif	0.587

Kaplan plot for ETS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ETS2

UniProt ID: P15036

Entrez ID: 2114

Protein name: Protein C-ets-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ETS2 in