DegronMD

Uniprot ID: P15036

Source protein: Protein C-ets-2

Source gene: ETS2

Class: DEG_COP1_1

Location: 300:311

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 59.525

COIL: 0.7752

CONS_SCORE: 0.4241

DSS_SCORE: 0.3729

HELIX: 0.1344

FCONS_SCORE: 1.0351

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S321F	TCGA-05-4249	LUAD	TCGA	SSLLDVQRVPSF	DEG_COP1_1	0.5
p.S321F	DO23891	LUAD	ICGC	SSLLDVQRVPSF	DEG_COP1_1	0.5
p.P309H	TCGA-EE-A29X	SKCM	TCGA	SSLLDVQRVPSF	DEG_COP1_1	0.7694
p.P309H	DO37595	SKCM	ICGC	SSLLDVQRVPSF	DEG_COP1_1	0.7694
p.P309S	TCGA-W3-AA1V	SKCM	TCGA	SSLLDVQRVPSF	DEG_COP1_1	0.6752
p.P309S	DO51276	SKCM	ICGC	SSLLDVQRVPSF	DEG_COP1_1	0.6752
p.R307Q	DO233801	GACA	ICGC	SSLLDVQRVPSF	DEG_COP1_1	0.6218
p.C318R	DO222395	MELA	ICGC	SSLLDVQRVPSF	DEG_COP1_1	0.1389
p.F311L	SIDM00057	Neuroblastoma	GDSC	SSLLDVQRVPSF	DEG_COP1_1	0.587
p.F311L	ACH-002389	Neuroblastoma	CCLE	SSLLDVQRVPSF	DEG_COP1_1	0.587
p.F311L	ACN	autonomic_ganglia	COSMIC	SSLLDVQRVPSF	DEG_COP1_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15036	Protein C-ets-2	DEG_COP1_1	300:311	SSLLDVQRVPSF	COP1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons