DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EETEETPVPEP
Uniprot ID:
Q8NFB2
Source protein:
Transmembrane protein 185A
Source gene:
TMEM185A
Class:
DEG_COP1_1
Location:
305:315
E3 ligase:
COP1
DEGRON score:
0.6476
ASA_SCORE:
112.9727
COIL:
0.9346
CONS_SCORE:
0.4112
DSS_SCORE:
0.6705
HELIX:
0.0518
FCONS_SCORE:
0.9482
RIG_SCORE:
0.6759
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TMEM185A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EETEETPVPEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NFB2
Transmembrane protein 185A
DEG_COP1_1
305:315
EETEETPVPEP
COP1
0.6476
More...