DegronMD

Uniprot ID: O75064

Source protein: DENN domain-containing protein 4B

Source gene: DENND4B

Class: DEG_COP1_1

Location: 27:34

E3 ligase: COP1

DEGRON score: 0.8765

ASA_SCORE: 85.225

COIL: 0.7358

CONS_SCORE: 0.3066

DSS_SCORE: 0.5857

HELIX: 0.079

FCONS_SCORE: 0.812

RIG_SCORE: 0.7335

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R39H	TCGA-2W-A8YY	CESC	TCGA	EETWVPEP	DEG_COP1_1	0.1944
p.R39H	DO223732	CESC	ICGC	EETWVPEP	DEG_COP1_1	0.1944
p.L18F	TCGA-AP-A0LM	UCEC	TCGA	EETWVPEP	DEG_COP1_1	0.0833
p.L18F	DO43306	UCEC	ICGC	EETWVPEP	DEG_COP1_1	0.0833
p.R39C	TCGA-D1-A1NZ	UCEC	TCGA	EETWVPEP	DEG_COP1_1	0.1944
p.R39C	DO41536	UCEC	ICGC	EETWVPEP	DEG_COP1_1	0.1944
p.P32A	TCGA-SH-A7BH	MESO	TCGA	EETWVPEP	DEG_COP1_1	0.7503
p.A19V	DO229268	THCA	ICGC	EETWVPEP	DEG_COP1_1	0.1111
p.R42W	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	EETWVPEP	DEG_COP1_1	0.1111
p.R42W	SIDM00736	Non-Cancerous	GDSC	EETWVPEP	DEG_COP1_1	0.1111
p.R42W	ACH-000886	Lung Cancer	CCLE	EETWVPEP	DEG_COP1_1	0.1111
p.R42W	ACH-002366	Non-Cancerous	CCLE	EETWVPEP	DEG_COP1_1	0.1111
p.A19T	ACH-000999	Colon/Colorectal Cancer	CCLE	EETWVPEP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75064	DENN domain-containing protein 4B	DEG_COP1_1	27:34	EETWVPEP	COP1	0.8765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons