DegronMD - O75064(DENND4B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E661D	TCGA-19-5956	GBM	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.2778
p.E661D	DO13863	GBM	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.2778
p.R39H	TCGA-2W-A8YY	CESC	TCGA	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1944
p.R39H	DO223732	CESC	ICGC	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1944
p.D1222N	TCGA-A5-A0G2	UCEC	TCGA	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0556
p.D1222N	DO233842	GACA	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0556
p.D1222N	DO41235	UCEC	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0556
p.Q1201H	TCGA-A5-A0G2	UCEC	TCGA	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.3056
p.Q1201H	DO41235	UCEC	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.3056
p.E678G	TCGA-A8-A09Z	BRCA	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1111
p.E678G	TCGA-A8-A09Z	BRCA	TCGA	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.25
p.E678G	DO5521	BRCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1111
p.E678G	DO5521	BRCA	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.25
p.L18F	TCGA-AP-A0LM	UCEC	TCGA	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.0833
p.L18F	DO43306	UCEC	ICGC	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.0833
p.A1217V	TCGA-AX-A06F	UCEC	TCGA	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.1944
p.A1217V	DO41752	UCEC	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.1944
p.P665L	TCGA-CG-5723	STAD	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation altering degron motif	0.6471
p.P665L	DO38376	STAD	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation altering degron motif	0.6471
p.R39C	TCGA-D1-A1NZ	UCEC	TCGA	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1944
p.R39C	DO41536	UCEC	ICGC	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1944
p.S677R	TCGA-D9-A6EC	SKCM	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation blocking phosphorylation signal	0.5833
p.S677R	TCGA-D9-A6EC	SKCM	TCGA	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation blocking phosphorylation signal	0.6667
p.S677R	DO50291	SKCM	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation blocking phosphorylation signal	0.5833
p.S677R	DO50291	SKCM	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation blocking phosphorylation signal	0.6667
p.P692R	TCGA-DY-A1DC	READ	TCGA	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.2222
p.P692R	DO36519	READ	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.2222
p.G676E	TCGA-FJ-A3Z7	BLCA	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1667
p.G676E	TCGA-FJ-A3Z7	BLCA	TCGA	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.1944
p.G676E	DO463	BLCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1667
p.G676E	DO463	BLCA	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.1944
p.E687K	TCGA-LP-A4AV	CESC	TCGA	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation altering degron motif	0.591
p.E687K	DO44275	CESC	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation altering degron motif	0.591
p.H657L	TCGA-NJ-A55R	LUAD	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1667
p.H657L	DO218947	LUAD	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1667
p.P32A	TCGA-SH-A7BH	MESO	TCGA	EETWVPEP	DEG_COP1_1	27:34	Mutation altering degron motif	0.7503
p.S1199G	DO49373	ALL	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.25
p.H657D	DO224944	BRCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1667
p.E678K	DO222919	BTCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.1111
p.E678K	DO222919	BTCA	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.25
p.R1206W	DO233190	GACA	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation altering degron motif	0.7523
p.R1206W	DO222557	MELA	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation altering degron motif	0.7523
p.E673K	DO23232	LINC	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.25
p.E673K	DO23232	LINC	ICGC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.1111
p.E659D	DO23509	LIRI	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	663:670	Mutation rewiring degron network	0.2222
p.P1193L	DO220877	MELA	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0833
p.P1212S	DO222418	MELA	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation altering degron motif	0.6752
p.L1198R	DO35442	PACA	ICGC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.2222
p.A19V	DO229268	THCA	ICGC	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1111
p.R1206Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation altering degron motif	0.6218
p.R1206Q	ACH-000980	Lung Cancer	CCLE	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation altering degron motif	0.6218
p.R1206Q	NCI-H1155	lung	COSMIC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation altering degron motif	0.6218
p.R42W	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1111
p.R42W	SIDM00736	Non-Cancerous	GDSC	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1111
p.R42W	ACH-000886	Lung Cancer	CCLE	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1111
p.R42W	ACH-002366	Non-Cancerous	CCLE	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1111
p.P1193S	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0833
p.P1193S	ACH-000873	Esophageal Cancer	CCLE	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0833
p.P1193S	KYSE-270	oesophagus	COSMIC	TLDSRPSVPSP	DEG_COP1_1	1202:1212	Mutation rewiring degron network	0.0833
p.P685L	SIDM01398	Melanoma	GDSC	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation altering degron motif	0.7582
p.P685L	ACH-000661	Skin Cancer	CCLE	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation altering degron motif	0.7582
p.G694D	ACH-000973	Bladder Cancer	CCLE	VFITPPEE	DEG_SCF_FBW7_2	681:688	Mutation rewiring degron network	0.1667
p.A19T	ACH-000999	Colon/Colorectal Cancer	CCLE	EETWVPEP	DEG_COP1_1	27:34	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND4B

UniProt ID: O75064

Entrez ID: 9909

Protein name: DENN domain-containing protein 4B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DENND4B in