DegronMD

Uniprot ID: O75064

Source protein: DENN domain-containing protein 4B

Source gene: DENND4B

Class: DEG_SCF_FBW7_2

Location: 663:670

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 80.9875

COIL: 0.7605

CONS_SCORE: 0.3637

DSS_SCORE: 0.6875

HELIX: 0.1084

FCONS_SCORE: 0.995

RIG_SCORE: 0.7132

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E661D	TCGA-19-5956	GBM	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	0.2778
p.E661D	DO13863	GBM	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.2778
p.E678G	TCGA-A8-A09Z	BRCA	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	0.1111
p.E678G	DO5521	BRCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.1111
p.P665L	TCGA-CG-5723	STAD	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	0.6471
p.P665L	DO38376	STAD	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.6471
p.S677R	TCGA-D9-A6EC	SKCM	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	0.5833
p.S677R	DO50291	SKCM	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.5833
p.G676E	TCGA-FJ-A3Z7	BLCA	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	0.1667
p.G676E	DO463	BLCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.1667
p.H657L	TCGA-NJ-A55R	LUAD	TCGA	PEPTPLVE	DEG_SCF_FBW7_2	0.1667
p.H657L	DO218947	LUAD	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.1667
p.H657D	DO224944	BRCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.1667
p.E678K	DO222919	BTCA	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.1111
p.E673K	DO23232	LINC	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.25
p.E659D	DO23509	LIRI	ICGC	PEPTPLVE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75064	DENN domain-containing protein 4B	DEG_SCF_FBW7_2	663:670	PEPTPLVE	FBXW7	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons