DegronMD

Uniprot ID: O75064

Source protein: DENN domain-containing protein 4B

Source gene: DENND4B

Class: DEG_COP1_1

Location: 1202:1212

E3 ligase: COP1

DEGRON score: 0.8041

ASA_SCORE: 78.7091

COIL: 0.8402

CONS_SCORE: 0.3154

DSS_SCORE: 0.5338

HELIX: 0.0184

FCONS_SCORE: 0.8713

RIG_SCORE: 0.6678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1222N	TCGA-A5-A0G2	UCEC	TCGA	TLDSRPSVPSP	DEG_COP1_1	0.0556
p.D1222N	DO233842	GACA	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.0556
p.D1222N	DO41235	UCEC	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.0556
p.Q1201H	TCGA-A5-A0G2	UCEC	TCGA	TLDSRPSVPSP	DEG_COP1_1	0.3056
p.Q1201H	DO41235	UCEC	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.3056
p.A1217V	TCGA-AX-A06F	UCEC	TCGA	TLDSRPSVPSP	DEG_COP1_1	0.1944
p.A1217V	DO41752	UCEC	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.1944
p.S1199G	DO49373	ALL	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.25
p.R1206W	DO233190	GACA	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.7523
p.R1206W	DO222557	MELA	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.7523
p.P1193L	DO220877	MELA	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.0833
p.P1212S	DO222418	MELA	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.6752
p.L1198R	DO35442	PACA	ICGC	TLDSRPSVPSP	DEG_COP1_1	0.2222
p.R1206Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	TLDSRPSVPSP	DEG_COP1_1	0.6218
p.R1206Q	ACH-000980	Lung Cancer	CCLE	TLDSRPSVPSP	DEG_COP1_1	0.6218
p.R1206Q	NCI-H1155	lung	COSMIC	TLDSRPSVPSP	DEG_COP1_1	0.6218
p.P1193S	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	TLDSRPSVPSP	DEG_COP1_1	0.0833
p.P1193S	ACH-000873	Esophageal Cancer	CCLE	TLDSRPSVPSP	DEG_COP1_1	0.0833
p.P1193S	KYSE-270	oesophagus	COSMIC	TLDSRPSVPSP	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75064	DENN domain-containing protein 4B	DEG_COP1_1	1202:1212	TLDSRPSVPSP	COP1	0.8041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons