DegronMD

Uniprot ID: O75064

Source protein: DENN domain-containing protein 4B

Source gene: DENND4B

Class: DEG_SCF_FBW7_2

Location: 681:688

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 83.925

COIL: 0.803

CONS_SCORE: 0.4464

DSS_SCORE: 0.675

HELIX: 0.0125

FCONS_SCORE: 1.2527

RIG_SCORE: 0.7302

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E678G	TCGA-A8-A09Z	BRCA	TCGA	VFITPPEE	DEG_SCF_FBW7_2	0.25
p.E678G	DO5521	BRCA	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.25
p.S677R	TCGA-D9-A6EC	SKCM	TCGA	VFITPPEE	DEG_SCF_FBW7_2	0.6667
p.S677R	DO50291	SKCM	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.6667
p.P692R	TCGA-DY-A1DC	READ	TCGA	VFITPPEE	DEG_SCF_FBW7_2	0.2222
p.P692R	DO36519	READ	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.2222
p.G676E	TCGA-FJ-A3Z7	BLCA	TCGA	VFITPPEE	DEG_SCF_FBW7_2	0.1944
p.G676E	DO463	BLCA	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.1944
p.E687K	TCGA-LP-A4AV	CESC	TCGA	VFITPPEE	DEG_SCF_FBW7_2	0.591
p.E687K	DO44275	CESC	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.591
p.E678K	DO222919	BTCA	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.25
p.E673K	DO23232	LINC	ICGC	VFITPPEE	DEG_SCF_FBW7_2	0.1111
p.P685L	SIDM01398	Melanoma	GDSC	VFITPPEE	DEG_SCF_FBW7_2	0.7582
p.P685L	ACH-000661	Skin Cancer	CCLE	VFITPPEE	DEG_SCF_FBW7_2	0.7582
p.G694D	ACH-000973	Bladder Cancer	CCLE	VFITPPEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75064	DENN domain-containing protein 4B	DEG_SCF_FBW7_2	681:688	VFITPPEE	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons