DegronMD

Uniprot ID: Q86TY3

Source protein: Armadillo-like helical domain-containing protein 4

Source gene: ARMH4

Class: DEG_COP1_1

Location: 677:686

E3 ligase: COP1

DEGRON score: 0.9898

ASA_SCORE: 76.2

COIL: 0.7561

CONS_SCORE: 0.8266

DSS_SCORE: 0.4451

HELIX: 0.1454

FCONS_SCORE: 1.156

RIG_SCORE: 0.8094

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E670K	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	EGATYQVPDA	DEG_COP1_1	0.1389
p.E670K	KYSE-180	oesophagus	COSMIC	EGATYQVPDA	DEG_COP1_1	0.1389
p.E688K	SIDM01608	Endometrial Carcinoma	GDSC	EGATYQVPDA	DEG_COP1_1	0.2778
p.D674N	SIDM01577	Plasma Cell Myeloma	GDSC	EGATYQVPDA	DEG_COP1_1	0.25
p.M673I	SIDM01577	Plasma Cell Myeloma	GDSC	EGATYQVPDA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TY3	Armadillo-like helical domain-containing protein 4	DEG_COP1_1	677:686	EGATYQVPDA	COP1	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons