DegronMD - Q86TY3(ARMH4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E670K	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	EGATYQVPDA	DEG_COP1_1	677:686	Mutation rewiring degron network	0.1389
p.E670K	KYSE-180	oesophagus	COSMIC	EGATYQVPDA	DEG_COP1_1	677:686	Mutation rewiring degron network	0.1389
p.M144I	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.1944
p.M144I	NCI-H2135	lung	COSMIC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.1944
p.P114R	SIDM00966	Ovarian Carcinoma	GDSC	STPTESGVPSA	DEG_COP1_1	112:122	Mutation altering degron motif	0.6401
p.P114R	SIDM00966	Ovarian Carcinoma	GDSC	VSTPTES	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7512
p.P114R	OVCA433	ovary	COSMIC	STPTESGVPSA	DEG_COP1_1	112:122	Mutation altering degron motif	0.6401
p.P114R	OVCA433	ovary	COSMIC	VSTPTES	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7512
p.S166R	SIDM00102	Mesothelioma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.0556
p.S166R	H2461	pleura	COSMIC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.0556
p.A148T	SIDM01147	Gastric Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.3056
p.E162G	SIDM00537	Colorectal Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.1667
p.E162G	GP5d	large intestine	COSMIC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.1667
p.N264K	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPDKE	DEG_SCF_FBW7_2	250:255	Mutation rewiring degron network	0.0833
p.E688K	SIDM01608	Endometrial Carcinoma	GDSC	EGATYQVPDA	DEG_COP1_1	677:686	Mutation rewiring degron network	0.2778
p.D674N	SIDM01577	Plasma Cell Myeloma	GDSC	EGATYQVPDA	DEG_COP1_1	677:686	Mutation rewiring degron network	0.25
p.M673I	SIDM01577	Plasma Cell Myeloma	GDSC	EGATYQVPDA	DEG_COP1_1	677:686	Mutation rewiring degron network	0.2222
p.T146I	SIDM01611	Endometrial Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	149:156	Mutation rewiring degron network	0.25

Kaplan plot for ARMH4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARMH4

UniProt ID: Q86TY3

Entrez ID: 145407

Protein name: Armadillo-like helical domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARMH4 in