DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VSTPTES
Uniprot ID:
Q86TY3
Source protein:
Armadillo-like helical domain-containing protein 4
Source gene:
ARMH4
Class:
DEG_SCF_FBW7_1
Location:
111:117
E3 ligase:
FBXW7
DEGRON score:
0.9816
ASA_SCORE:
89.0571
COIL:
0.9541
CONS_SCORE:
0.549
DSS_SCORE:
0.7178
HELIX:
0.0127
FCONS_SCORE:
1.1615
RIG_SCORE:
0.5941
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P114R
SIDM00966
Ovarian Carcinoma
GDSC
VSTPTES
DEG_SCF_FBW7_1
0.7512
p.P114R
OVCA433
ovary
COSMIC
VSTPTES
DEG_SCF_FBW7_1
0.7512
Drug responses associated with ARMH4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTPTES
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86TY3
Armadillo-like helical domain-containing protein 4
DEG_SCF_FBW7_1
111:117
VSTPTES
FBXW7
0.9816
More...