DegronMD

Uniprot ID: Q86TY3

Source protein: Armadillo-like helical domain-containing protein 4

Source gene: ARMH4

Class: DEG_SCF_FBW7_1

Location: 149:156

E3 ligase: FBXW7

DEGRON score: 0.577

ASA_SCORE: 84.7875

COIL: 0.9119

CONS_SCORE: 0.4852

DSS_SCORE: 0.312

HELIX: 0.0244

FCONS_SCORE: 0.9717

RIG_SCORE: 0.7836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M144I	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	0.1944
p.M144I	NCI-H2135	lung	COSMIC	ITATPSLT	DEG_SCF_FBW7_1	0.1944
p.S166R	SIDM00102	Mesothelioma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	0.0556
p.S166R	H2461	pleura	COSMIC	ITATPSLT	DEG_SCF_FBW7_1	0.0556
p.A148T	SIDM01147	Gastric Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	0.3056
p.E162G	SIDM00537	Colorectal Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	0.1667
p.E162G	GP5d	large_intestine	COSMIC	ITATPSLT	DEG_SCF_FBW7_1	0.1667
p.T146I	SIDM01611	Endometrial Carcinoma	GDSC	ITATPSLT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TY3	Armadillo-like helical domain-containing protein 4	DEG_SCF_FBW7_1	149:156	ITATPSLT	FBXW7	0.577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons