DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPDKE
Uniprot ID:
Q86TY3
Source protein:
Armadillo-like helical domain-containing protein 4
Source gene:
ARMH4
Class:
DEG_SCF_FBW7_2
Location:
250:255
E3 ligase:
FBXW7
DEGRON score:
0.6216
ASA_SCORE:
103.25
COIL:
0.9007
CONS_SCORE:
0.3472
DSS_SCORE:
0.807
HELIX:
0.0475
FCONS_SCORE:
0.7456
RIG_SCORE:
0.5987
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N264K
SIDM01072
Squamous Cell Lung Carcinoma
GDSC
LTPDKE
DEG_SCF_FBW7_2
0.0833
Drug responses associated with ARMH4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPDKE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86TY3
Armadillo-like helical domain-containing protein 4
DEG_SCF_FBW7_2
250:255
LTPDKE
FBXW7
0.6216
More...