DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
STPTESGVPSA
Uniprot ID:
Q86TY3
Source protein:
Armadillo-like helical domain-containing protein 4
Source gene:
ARMH4
Class:
DEG_COP1_1
Location:
112:122
E3 ligase:
COP1
DEGRON score:
0.9965
ASA_SCORE:
81.1273
COIL:
0.915
CONS_SCORE:
0.5142
DSS_SCORE:
0.6976
HELIX:
0.0508
FCONS_SCORE:
1.0667
RIG_SCORE:
0.6075
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P114R
SIDM00966
Ovarian Carcinoma
GDSC
STPTESGVPSA
DEG_COP1_1
0.6401
p.P114R
OVCA433
ovary
COSMIC
STPTESGVPSA
DEG_COP1_1
0.6401
Drug responses associated with ARMH4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of STPTESGVPSA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86TY3
Armadillo-like helical domain-containing protein 4
DEG_COP1_1
112:122
STPTESGVPSA
COP1
0.9965
More...