DegronMD

Uniprot ID: Q9C0I9

Source protein: Leucine-rich repeat-containing protein 27

Source gene: LRRC27

Class: DEG_COP1_1

Location: 2:12

E3 ligase: COP1

DEGRON score: 0.9522

ASA_SCORE: 79.3

COIL: 0.7756

CONS_SCORE: 0.515

DSS_SCORE: 0.7205

HELIX: 0.0592

FCONS_SCORE: 1.0077

RIG_SCORE: 0.6679

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S11F	TCGA-B5-A1MR	UCEC	TCGA	EGSSSYEVPSV	DEG_COP1_1	0.7982
p.S11F	DO41758	UCEC	ICGC	EGSSSYEVPSV	DEG_COP1_1	0.7982
p.N8I	DO222404	BTCA	ICGC	EGSSSYEVPSV	DEG_COP1_1	0.728
p.P10S	DO229453	SKCA	ICGC	EGSSSYEVPSV	DEG_COP1_1	0.6752
p.A14V	TCGA-BG-A222	UCEC	TCGA	EGSSSYEVPSV	DEG_COP1_1	0.2778
p.A14V	DO42977	UCEC	ICGC	EGSSSYEVPSV	DEG_COP1_1	0.2778
p.A15D	TCGA-13-2060	OV	TCGA	EGSSSYEVPSV	DEG_COP1_1	0.25
p.A15D	DO30170	OV	ICGC	EGSSSYEVPSV	DEG_COP1_1	0.25
p.G22C	TCGA-BF-A1Q0	SKCM	TCGA	EGSSSYEVPSV	DEG_COP1_1	0.0556
p.G22C	DO47374	SKCM	ICGC	EGSSSYEVPSV	DEG_COP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0I9	Leucine-rich repeat-containing protein 27	DEG_COP1_1	2:12	EGSSSYEVPSV	COP1	0.9522	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons