DegronMD - Q9C0I9(LRRC27)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A15D	TCGA-13-2060	OV	TCGA	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation rewiring degron network	0.25
p.A15D	DO30170	OV	ICGC	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation rewiring degron network	0.25
p.S11F	TCGA-B5-A1MR	UCEC	TCGA	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation altering degron motif	0.7982
p.S11F	DO41758	UCEC	ICGC	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation altering degron motif	0.7982
p.R331Q	TCGA-B5-A1MR	UCEC	TCGA	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1111
p.R331Q	DO33208	PACA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1111
p.R331Q	DO41758	UCEC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1111
p.G22C	TCGA-BF-A1Q0	SKCM	TCGA	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation rewiring degron network	0.0556
p.G22C	DO47374	SKCM	ICGC	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation rewiring degron network	0.0556
p.A14V	TCGA-BG-A222	UCEC	TCGA	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation rewiring degron network	0.2778
p.A14V	DO42977	UCEC	ICGC	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation rewiring degron network	0.2778
p.A329V	TCGA-BR-4184	STAD	TCGA	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1667
p.D321N	TCGA-L5-A893	ESCA	TCGA	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.5821
p.N8I	DO222404	BTCA	ICGC	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation altering degron motif	0.728
p.V318A	DO227987	COCA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.6936
p.S314F	DO234462	ESAD	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.3056
p.S314F	DO220899	MELA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.3056
p.G330C	DO233737	GACA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1389
p.R314M	DO233882	GACA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.3056
p.I318F	DO228278	LICA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation altering degron motif	0.6304
p.G329V	DO229032	LICA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1667
p.M328L	DO231598	LINC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1944
p.M328L	DO231553	LINC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1944
p.R314S	DO23268	LINC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.3056
p.V331L	DO52020	LUSC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1111
p.P10S	DO229453	SKCA	ICGC	EGSSSYEVPSV	DEG_COP1_1	2:12	Mutation altering degron motif	0.6752
p.V331M	SIDM01966	Colorectal Carcinoma	GDSC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.1111
p.P313S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.2778
p.P313S	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	SRSILPDLL	DEG_APCC_DBOX_1	315:323	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC27

UniProt ID: Q9C0I9

Entrez ID: 80313

Protein name: Leucine-rich repeat-containing protein 27

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC27 in