DegronMD

Uniprot ID: Q9C0I9

Source protein: Leucine-rich repeat-containing protein 27

Source gene: LRRC27

Class: DEG_APCC_DBOX_1

Location: 315:323

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.927

ASA_SCORE: 70.7889

COIL: 0.6033

CONS_SCORE: 0.6595

DSS_SCORE: 0.3395

HELIX: 0.3563

FCONS_SCORE: 1.2409

RIG_SCORE: 0.7406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R331Q	TCGA-B5-A1MR	UCEC	TCGA	SRSILPDLL	DEG_APCC_DBOX_1	0.1111
p.R331Q	DO33208	PACA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1111
p.R331Q	DO41758	UCEC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1111
p.A329V	TCGA-BR-4184	STAD	TCGA	SRSILPDLL	DEG_APCC_DBOX_1	0.1667
p.D321N	TCGA-L5-A893	ESCA	TCGA	SRSILPDLL	DEG_APCC_DBOX_1	0.5821
p.V318A	DO227987	COCA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.6936
p.S314F	DO234462	ESAD	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.3056
p.S314F	DO220899	MELA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.3056
p.G330C	DO233737	GACA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1389
p.R314M	DO233882	GACA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.3056
p.I318F	DO228278	LICA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.6304
p.G329V	DO229032	LICA	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1667
p.M328L	DO231598	LINC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1944
p.M328L	DO231553	LINC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1944
p.R314S	DO23268	LINC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.3056
p.V331L	DO52020	LUSC	ICGC	SRSILPDLL	DEG_APCC_DBOX_1	0.1111
p.V331M	SIDM01966	Colorectal Carcinoma	GDSC	SRSILPDLL	DEG_APCC_DBOX_1	0.1111
p.P313S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	SRSILPDLL	DEG_APCC_DBOX_1	0.2778
p.P313S	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	SRSILPDLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0I9	Leucine-rich repeat-containing protein 27	DEG_APCC_DBOX_1	315:323	SRSILPDLL	APC,CDC20,FZR1	0.927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons