DegronMD

Uniprot ID: Q9NYD6

Source protein: Homeobox protein Hox-C10

Source gene: HOXC10

Class: DEG_COP1_1

Location: 140:148

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 56.0111

COIL: 0.7917

CONS_SCORE: 0.4922

DSS_SCORE: 0.3449

HELIX: 0.076

FCONS_SCORE: 1.1839

RIG_SCORE: 0.7188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S130Y	TCGA-AG-A002	READ	TCGA	EHEVPVPSY	DEG_COP1_1	0.0556
p.V145M	TCGA-D1-A17Q	UCEC	TCGA	EHEVPVPSY	DEG_COP1_1	0.7208
p.V145M	DO41903	UCEC	ICGC	EHEVPVPSY	DEG_COP1_1	0.7208
p.E142K	TCGA-VS-A9UC	CESC	TCGA	EHEVPVPSY	DEG_COP1_1	0.7022
p.E142K	DO219732	CESC	ICGC	EHEVPVPSY	DEG_COP1_1	0.7022
p.P144S	DO229056	LICA	ICGC	EHEVPVPSY	DEG_COP1_1	0.5641
p.A151V	DO32817	PACA	ICGC	EHEVPVPSY	DEG_COP1_1	0.25
p.A151V	SIDM01135	Pancreatic Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	0.25
p.A151V	ACH-000060	Pancreatic Cancer	CCLE	EHEVPVPSY	DEG_COP1_1	0.25
p.A151V	PANC-10-05	pancreas	COSMIC	EHEVPVPSY	DEG_COP1_1	0.25
p.E142D	SIDM00957	Colorectal Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	SIDM01177	B-Lymphoblastic Leukemia	GDSC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	SIDM00542	Glioblastoma	GDSC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	SIDM00100	Mesothelioma	GDSC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	SUP-B8	haematopoietic_and_lymphoid_tissue	COSMIC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	COLO-678	large_intestine	COSMIC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	D-392MG	central_nervous_system	COSMIC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E142D	H2595	pleura	COSMIC	EHEVPVPSY	DEG_COP1_1	0.5647
p.E140A	SIDM00399	Head and Neck Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	0.7701
p.E140A	SCC90	upper_aerodigestive_tract	COSMIC	EHEVPVPSY	DEG_COP1_1	0.7701
p.S156C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EHEVPVPSY	DEG_COP1_1	0.5556
p.S156C	SIDM00264	Ewing's Sarcoma	GDSC	EHEVPVPSY	DEG_COP1_1	0.5556
p.P132H	SIDM00721	Small Cell Lung Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	0.1111
p.P132H	ACH-002171	Lung Cancer	CCLE	EHEVPVPSY	DEG_COP1_1	0.1111
p.P132H	NCI-H250	lung	COSMIC	EHEVPVPSY	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYD6	Homeobox protein Hox-C10	DEG_COP1_1	140:148	EHEVPVPSY	COP1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EHEVPVPSY

Degron related mutations and impact score

Drug responses associated with HOXC10 mutations

All proteins holding degron of EHEVPVPSY