DegronMD - Q9NYD6(HOXC10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A167T	TCGA-66-2782	LUSC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2778
p.A167T	DO26680	LUSC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2778
p.A167D	TCGA-66-2782	LUSC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2778
p.A167D	DO26680	LUSC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.2778
p.S130Y	TCGA-AG-A002	READ	TCGA	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.0556
p.E171K	TCGA-B5-A1MR	UCEC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1667
p.E171K	DO41758	UCEC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1667
p.E171K	SIDM02013	Colorectal Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1667
p.P162S	TCGA-BG-A0VX	UCEC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.P162S	DO43923	UCEC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.A172T	TCGA-BR-4184	STAD	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.A172T	DO38328	STAD	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.V145M	TCGA-D1-A17Q	UCEC	TCGA	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.7208
p.V145M	DO41903	UCEC	ICGC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.7208
p.P173L	TCGA-FR-A726	SKCM	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1111
p.P173L	DO48665	SKCM	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1111
p.E142K	TCGA-VS-A9UC	CESC	TCGA	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.7022
p.E142K	DO219732	CESC	ICGC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.7022
p.C164F	DO229034	LICA	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.5996
p.P144S	DO229056	LICA	ICGC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5641
p.A151V	DO32817	PACA	ICGC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.25
p.A151V	DO32817	PACA	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.A151V	SIDM01135	Pancreatic Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.25
p.A151V	SIDM01135	Pancreatic Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.A151V	ACH-000060	Pancreatic Cancer	CCLE	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.25
p.A151V	ACH-000060	Pancreatic Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.A151V	PANC-10-05	pancreas	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.25
p.A151V	PANC-10-05	pancreas	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.1389
p.E142D	SIDM00957	Colorectal Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	SIDM01177	B-Lymphoblastic Leukemia	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	SIDM00542	Glioblastoma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	SIDM00100	Mesothelioma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	SUP-B8	haematopoietic and lymphoid tissue	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	COLO-678	large intestine	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	D-392MG	central nervous system	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E142D	H2595	pleura	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.5647
p.E140A	SIDM00399	Head and Neck Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.7701
p.E140A	SCC90	upper aerodigestive tract	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation altering degron motif	0.7701
p.D159H	SIDM00652	Small Cell Lung Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6577
p.D159H	ACH-000780	Lung Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6577
p.D159H	NCI-H1105	lung	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6577
p.S156C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation blocking phosphorylation signal	0.5556
p.S156C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation blocking phosphorylation signal	0.7222
p.S156C	SIDM00264	Ewing's Sarcoma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation blocking phosphorylation signal	0.5556
p.S156C	SIDM00264	Ewing's Sarcoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation blocking phosphorylation signal	0.7222
p.S165P	SIDM01045	Endometrial Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.S165P	ACH-000978	Endometrial/Uterine Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.S165P	EN	endometrium	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.6752
p.P132H	SIDM00721	Small Cell Lung Carcinoma	GDSC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.1111
p.P132H	ACH-002171	Lung Cancer	CCLE	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.1111
p.P132H	NCI-H250	lung	COSMIC	EHEVPVPSY	DEG_COP1_1	140:148	Mutation rewiring degron network	0.1111
p.G166R	SIDM01582	Gastric Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.3056
p.G166R	ACH-000507	Gastric Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation rewiring degron network	0.3056
p.S165A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	158:165	Mutation altering degron motif	0.7588

Kaplan plot for HOXC10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOXC10

UniProt ID: Q9NYD6

Entrez ID: 3226

Protein name: Homeobox protein Hox-C10 (Homeobox protein Hox-3I)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOXC10 in