DegronMD

Uniprot ID: Q9NYD6

Source protein: Homeobox protein Hox-C10

Source gene: HOXC10

Class: DEG_SCF_FBW7_1

Location: 158:165

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 60.1125

COIL: 0.8465

CONS_SCORE: 0.4367

DSS_SCORE: 0.4616

HELIX: 0.0834

FCONS_SCORE: 0.9808

RIG_SCORE: 0.6739

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A167T	TCGA-66-2782	LUSC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	0.2778
p.A167T	DO26680	LUSC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.2778
p.A167D	TCGA-66-2782	LUSC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	0.2778
p.A167D	DO26680	LUSC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.2778
p.E171K	TCGA-B5-A1MR	UCEC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	0.1667
p.E171K	DO41758	UCEC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.1667
p.E171K	SIDM02013	Colorectal Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.1667
p.P162S	TCGA-BG-A0VX	UCEC	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	0.6752
p.P162S	DO43923	UCEC	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.6752
p.A172T	TCGA-BR-4184	STAD	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	0.1389
p.A172T	DO38328	STAD	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.1389
p.P173L	TCGA-FR-A726	SKCM	TCGA	LDKTPHCS	DEG_SCF_FBW7_1	0.1111
p.P173L	DO48665	SKCM	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.1111
p.C164F	DO229034	LICA	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.5996
p.A151V	DO32817	PACA	ICGC	LDKTPHCS	DEG_SCF_FBW7_1	0.1389
p.A151V	SIDM01135	Pancreatic Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.1389
p.A151V	ACH-000060	Pancreatic Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	0.1389
p.A151V	PANC-10-05	pancreas	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	0.1389
p.D159H	SIDM00652	Small Cell Lung Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.6577
p.D159H	ACH-000780	Lung Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	0.6577
p.D159H	NCI-H1105	lung	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	0.6577
p.S156C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.7222
p.S156C	SIDM00264	Ewing's Sarcoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.7222
p.S165P	SIDM01045	Endometrial Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.6752
p.S165P	ACH-000978	Endometrial/Uterine Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	0.6752
p.S165P	EN	endometrium	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	0.6752
p.G166R	SIDM01582	Gastric Carcinoma	GDSC	LDKTPHCS	DEG_SCF_FBW7_1	0.3056
p.G166R	ACH-000507	Gastric Cancer	CCLE	LDKTPHCS	DEG_SCF_FBW7_1	0.3056
p.S165A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	LDKTPHCS	DEG_SCF_FBW7_1	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDKTPHCS

Degron related mutations and impact score

Drug responses associated with HOXC10 mutations

All proteins holding degron of LDKTPHCS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYD6	Homeobox protein Hox-C10	DEG_SCF_FBW7_1	158:165	LDKTPHCS	FBXW7	0.9968	More...