DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_APCC_KENBOX_2

Location: 351:355

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9807

ASA_SCORE: 115.06

COIL: 0.5078

CONS_SCORE: 0.3348

DSS_SCORE: 0.4906

HELIX: 0.4612

FCONS_SCORE: 1.1456

RIG_SCORE: 0.7362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S342F	TCGA-33-6737	LUSC	TCGA	EKENM	DEG_APCC_KENBOX_2	0.0833
p.S342F	TCGA-85-8354	LUSC	TCGA	EKENM	DEG_APCC_KENBOX_2	0.0833
p.S342F	DO26866	LUSC	ICGC	EKENM	DEG_APCC_KENBOX_2	0.0833
p.S342F	DO45467	LUSC	ICGC	EKENM	DEG_APCC_KENBOX_2	0.0833
p.R344G	TCGA-BG-A222	UCEC	TCGA	EKENM	DEG_APCC_KENBOX_2	0.25
p.R344G	DO42977	UCEC	ICGC	EKENM	DEG_APCC_KENBOX_2	0.25
p.S360I	DO229029	LICA	ICGC	EKENM	DEG_APCC_KENBOX_2	0.1944
p.P353L	DO46996	RECA	ICGC	EKENM	DEG_APCC_KENBOX_2	0.7582
p.V351I	SIDM00582	Pancreatic Carcinoma	GDSC	EKENM	DEG_APCC_KENBOX_2	0.7076
p.V351I	KP-2	pancreas	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.7076
p.D352A	SISO	cervix	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.7793
p.L357F	NCI-H1770	lung	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.2778
p.L348F	COLO-741	large_intestine	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.25
p.L363F	COLO-741	large_intestine	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.1111
p.K344R	NCI-H810	lung	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.25
p.K359R	NCI-H810	lung	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.2222
p.E363Q	HT-1376	urinary_tract	COSMIC	EKENM	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_APCC_KENBOX_2	351:355	EKENM	APC,CDC20,FZR1	0.9807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons