DegronMD - Q9BVV6(KIAA0586)

FUNCTION: Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that prece... View more >>

GO - Biological processes (BP): cilium assembly [GO:0060271]; regulation of establishment of protein localization [GO:0070201]; smoothened signaling pathway [GO:0007224]

GO - Molecular function (MF):

GO - Cellular component (CC): centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; photoreceptor inner segment [GO:0001917]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R397L	TCGA-34-7107	LUSC	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8428
p.R397L	DO26449	LUSC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8428
p.R397C	DO233105	GACA	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8301
p.R397H	TCGA-17-Z045	LUAD	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.8244
p.D352A	SISO	cervix	COSMIC	EKENM	DEG_APCC_KENBOX_2	351:355	Mutation altering degron motif	0.7793
p.D1048V	TCGA-AD-6899	COAD	TCGA	PQPTPPCS	DEG_SCF_FBW7_1	1043:1050	Mutation altering degron motif	0.7785
p.P1101L	TCGA-A5-A1OF	UCEC	TCGA	LVNTPTVT	DEG_SCF_FBW7_1	1095:1102	Mutation altering degron motif	0.7582
p.P1116L	TCGA-EB-A431	SKCM	TCGA	VFTPTLS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.7582
p.P1116L	DO37671	SKCM	ICGC	VFTPTLS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.7582
p.P353L	DO46996	RECA	ICGC	EKENM	DEG_APCC_KENBOX_2	351:355	Mutation altering degron motif	0.7582
p.D393A	SISO	cervix	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	394:401	Mutation blocking ubiquitination signal	0.75
p.T1114M	TCGA-AP-A0LD	UCEC	TCGA	VFTPTLS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.7423
p.T1114M	DO41578	UCEC	ICGC	VFTPTLS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.7423
p.M1113T	NB1	autonomic ganglia	COSMIC	VFTPTLS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.7423
p.D401Y	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	394:401	Mutation altering degron motif	0.7325
p.M703V	L-428	haematopoietic and lymphoid tissue	COSMIC	VLPHGD	LIG_APCC_ABBA_1	702:707	Mutation altering degron motif	0.7208
p.M703V	OACM5-1	oesophagus	COSMIC	VLPHGD	LIG_APCC_ABBA_1	702:707	Mutation altering degron motif	0.7208
p.L706I	DO41020	UCEC	ICGC	VLPHGD	LIG_APCC_ABBA_1	702:707	Mutation altering degron motif	0.7174
p.A1042T	TCGA-A5-A2K7	UCEC	TCGA	VCTPLPT	DEG_SCF_FBW7_1	1036:1042	Mutation altering degron motif	0.7139
p.A1042T	TCGA-IB-7651	PAAD	TCGA	VCTPLPT	DEG_SCF_FBW7_1	1036:1042	Mutation altering degron motif	0.7139

Showing 1 to 20 of 150 entries

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Kaplan plot for KIAA0586 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA0586

UniProt ID: Q9BVV6

Entrez ID: 9786

Protein name: Protein TALPID3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA0586 in