DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_SCF_FBW7_1

Location: 1113:1119

E3 ligase: FBXW7

DEGRON score: 0.9475

ASA_SCORE: 90.1714

COIL: 0.9419

CONS_SCORE: 0.4532

DSS_SCORE: 0.4261

HELIX: 0.0219

FCONS_SCORE: 0.9462

RIG_SCORE: 0.8047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1114M	TCGA-AP-A0LD	UCEC	TCGA	VFTPTLS	DEG_SCF_FBW7_1	0.7423
p.T1114M	DO41578	UCEC	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.7423
p.P1109L	TCGA-D3-A5GU	SKCM	TCGA	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.P1109L	DO47584	SKCM	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.P1116L	TCGA-EB-A431	SKCM	TCGA	VFTPTLS	DEG_SCF_FBW7_1	0.7582
p.P1116L	DO37671	SKCM	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.7582
p.P1109A	DO229010	COCA	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.P1109A	DO229013	COCA	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.P1109A	DO229016	COCA	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.P1109A	DO229003	COCA	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.P1109A	DO229005	COCA	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.2222
p.C1105Y	DO233189	GACA	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.1111
p.C1105Y	SIDM01608	Endometrial Carcinoma	GDSC	VFTPTLS	DEG_SCF_FBW7_1	0.1111
p.C1105Y	ACH-000990	Endometrial/Uterine Cancer	CCLE	VFTPTLS	DEG_SCF_FBW7_1	0.1111
p.R1103G	DO45129	LIRI	ICGC	VFTPTLS	DEG_SCF_FBW7_1	0.0556
p.M1104T	NB1	autonomic_ganglia	COSMIC	VFTPTLS	DEG_SCF_FBW7_1	0.0833
p.M1113T	NB1	autonomic_ganglia	COSMIC	VFTPTLS	DEG_SCF_FBW7_1	0.7423
p.P1116S	C3A	liver	COSMIC	VFTPTLS	DEG_SCF_FBW7_1	0.6752
p.P1120S	KYSE-50	oesophagus	COSMIC	VFTPTLS	DEG_SCF_FBW7_1	0.3056
p.P1107S	C3A	liver	COSMIC	VFTPTLS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_SCF_FBW7_1	1113:1119	VFTPTLS	FBXW7	0.9475	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons