DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_SCF_FBW7_1

Location: 1036:1042

E3 ligase: FBXW7

DEGRON score: 0.9746

ASA_SCORE: 95.0571

COIL: 0.959

CONS_SCORE: 0.5435

DSS_SCORE: 0.4882

HELIX: 0.0081

FCONS_SCORE: 1.1104

RIG_SCORE: 0.7015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1033A	TCGA-A5-A1OF	UCEC	TCGA	VCTPLPT	DEG_SCF_FBW7_1	0.25
p.A1042T	TCGA-A5-A2K7	UCEC	TCGA	VCTPLPT	DEG_SCF_FBW7_1	0.7139
p.A1042T	TCGA-IB-7651	PAAD	TCGA	VCTPLPT	DEG_SCF_FBW7_1	0.7139
p.A1042T	TCGA-UY-A8OC	BLCA	TCGA	VCTPLPT	DEG_SCF_FBW7_1	0.7139
p.A1042T	SIDM02059	Colorectal Carcinoma	GDSC	VCTPLPT	DEG_SCF_FBW7_1	0.7139
p.P1052S	TCGA-EE-A29L	SKCM	TCGA	VCTPLPT	DEG_SCF_FBW7_1	0.0556
p.A1042V	SIDM01059	Melanoma	GDSC	VCTPLPT	DEG_SCF_FBW7_1	0.6936
p.A1042V	ACH-000915	Skin Cancer	CCLE	VCTPLPT	DEG_SCF_FBW7_1	0.6936
p.A1042V	IPC-298	skin	COSMIC	VCTPLPT	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_SCF_FBW7_1	1036:1042	VCTPLPT	FBXW7	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons