DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_SCF_FBW7_1

Location: 1095:1102

E3 ligase: FBXW7

DEGRON score: 0.937

ASA_SCORE: 98.8125

COIL: 0.9639

CONS_SCORE: 0.4524

DSS_SCORE: 0.511

HELIX: 0.0114

FCONS_SCORE: 0.9154

RIG_SCORE: 0.7552

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1101L	TCGA-A5-A1OF	UCEC	TCGA	LVNTPTVT	DEG_SCF_FBW7_1	0.7582
p.S1090F	TCGA-CJ-4638	KIRC	TCGA	LVNTPTVT	DEG_SCF_FBW7_1	0.1944
p.P1109L	TCGA-D3-A5GU	SKCM	TCGA	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1109L	DO47584	SKCM	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1109A	DO229010	COCA	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1109A	DO229013	COCA	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1109A	DO229016	COCA	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1109A	DO229003	COCA	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1109A	DO229005	COCA	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.C1105Y	DO233189	GACA	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.25
p.C1105Y	SIDM01608	Endometrial Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.25
p.C1105Y	ACH-000990	Endometrial/Uterine Cancer	CCLE	LVNTPTVT	DEG_SCF_FBW7_1	0.25
p.R1103G	DO45129	LIRI	ICGC	LVNTPTVT	DEG_SCF_FBW7_1	0.3056
p.G1088D	SIDM00450	Acute Myeloid Leukemia	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00351	Oral Cavity Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00585	Hepatocellular Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00024	Non-Cancerous	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00488	Colorectal Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00549	B-Lymphoblastic Leukemia	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00618	Hepatocellular Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM01449	Pancreatic Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM01617	Endometrial Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM00164	Biliary Tract Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM01694	B-Lymphoblastic Leukemia	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.G1088D	SIDM01443	Gastric Carcinoma	GDSC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.M1104T	NB1	autonomic_ganglia	COSMIC	LVNTPTVT	DEG_SCF_FBW7_1	0.2778
p.P1088S	KYSE-50	oesophagus	COSMIC	LVNTPTVT	DEG_SCF_FBW7_1	0.1389
p.P1107S	C3A	liver	COSMIC	LVNTPTVT	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVNTPTVT

Degron related mutations and impact score

Drug responses associated with KIAA0586 mutations

All proteins holding degron of LVNTPTVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_SCF_FBW7_1	1095:1102	LVNTPTVT	FBXW7	0.937	More...