DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_SCF_FBW7_1

Location: 1043:1050

E3 ligase: FBXW7

DEGRON score: 0.8881

ASA_SCORE: 96.8

COIL: 0.973

CONS_SCORE: 0.674

DSS_SCORE: 0.4961

HELIX: 0.0093

FCONS_SCORE: 1.4783

RIG_SCORE: 0.5932

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1033A	TCGA-A5-A1OF	UCEC	TCGA	PQPTPPCS	DEG_SCF_FBW7_1	0.0556
p.D1048V	TCGA-AD-6899	COAD	TCGA	PQPTPPCS	DEG_SCF_FBW7_1	0.7785
p.P1052S	TCGA-EE-A29L	SKCM	TCGA	PQPTPPCS	DEG_SCF_FBW7_1	0.2778
p.K1059N	SIDM00602	Gastric Carcinoma	GDSC	PQPTPPCS	DEG_SCF_FBW7_1	0.0833
p.K1059N	ACH-000919	Gastric Cancer	CCLE	PQPTPPCS	DEG_SCF_FBW7_1	0.0833
p.K1059N	IM-95	stomach	COSMIC	PQPTPPCS	DEG_SCF_FBW7_1	0.0833
p.N1054K	SIDM00674	Non-Cancerous	GDSC	PQPTPPCS	DEG_SCF_FBW7_1	0.2222
p.N1054K	SIDM00675	Breast Carcinoma	GDSC	PQPTPPCS	DEG_SCF_FBW7_1	0.2222
p.N1054K	SIDM01009	Neuroblastoma	GDSC	PQPTPPCS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_SCF_FBW7_1	1043:1050	PQPTPPCS	FBXW7	0.8881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons