DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: LIG_APCC_ABBA_1

Location: 702:707

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9946

ASA_SCORE: 84.4167

COIL: 0.9412

CONS_SCORE: 0.3622

DSS_SCORE: 0.4749

HELIX: 0.0253

FCONS_SCORE: 0.7362

RIG_SCORE: 0.692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R709Q	TCGA-AG-A002	READ	TCGA	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.R709Q	TCGA-B5-A0JY	UCEC	TCGA	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.R709Q	TCGA-D1-A16X	UCEC	TCGA	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.R709Q	TCGA-D1-A17Q	UCEC	TCGA	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.R709Q	SIDM00118	Colorectal Carcinoma	GDSC	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.R709Q	ACH-001081	Colon/Colorectal Cancer	CCLE	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.R709Q	HCC2998	large_intestine	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.D694Y	TCGA-B5-A11E	UCEC	TCGA	VLPHGD	LIG_APCC_ABBA_1	0.1111
p.D715N	DO219643	BRCA	ICGC	VLPHGD	LIG_APCC_ABBA_1	0.5556
p.L706I	DO41020	UCEC	ICGC	VLPHGD	LIG_APCC_ABBA_1	0.7174
p.Y717H	SIDM00680	Colorectal Carcinoma	GDSC	VLPHGD	LIG_APCC_ABBA_1	0.0556
p.Y717H	LS-180	large_intestine	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.0556
p.Y700C	SIDM01164	Glioma	GDSC	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.Y700C	ACH-000883	Brain Cancer	CCLE	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.Y700C	SW1783	central_nervous_system	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.2778
p.D694V	SIDM00537	Colorectal Carcinoma	GDSC	VLPHGD	LIG_APCC_ABBA_1	0.1111
p.D694V	ACH-000982	Colon/Colorectal Cancer	CCLE	VLPHGD	LIG_APCC_ABBA_1	0.1111
p.D694V	ACH-001345	Colon/Colorectal Cancer	CCLE	VLPHGD	LIG_APCC_ABBA_1	0.1111
p.D694V	GP5d	large_intestine	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.1111
p.M703V	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.7208
p.M703V	OACM5-1	oesophagus	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.7208
p.M717T	HCT-15	large_intestine	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.0556
p.R700Q	HCC2998	large_intestine	COSMIC	VLPHGD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	LIG_APCC_ABBA_1	702:707	VLPHGD	APC,CDC20,FZR1	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons